4-Amino-6-methyl-5-thio-1,2,4-triazin-3-one 1 was reacted with phenacyl bromide in the presence of triethylamine in acetonitrile to give the corresponding 5-phenacylthio derivative 2.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

122 KiB

Open AccessShort Note

3-Amino-9-methyl-2H,6H--[1,2,4]triazino[5,4-b][1,3,4]thiadiazin-6-one

by Majid M. Heravi, Ghadir Rajabzadeh, Mohammad Rahimizadeh, Mehdi Bakavoli and Mitra Ghassemzadeh

Molecules 2001, 6(12), M238; https://doi.org/10.3390/M238 - 25 May 2001

Cited by 2 | Viewed by 3899

Abstract

Condensation of 4-amino-6-methyl-5-thio-1,2,4-triazin-3-one 1 with chloro acetonitrile in the presence of triethey amine afforded the corresponding 5-thiocyanomethyl derivative 2.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

113 KiB

Open AccessShort Note

4,7,7-Trimethyl-bicyclo [2.2.1]heptan-2-ol

by Badia Ait Allal, Larbi El Firdoussi, Smail Allaoud and Abdellah Karim

Molecules 2001, 6(12), M239; https://doi.org/10.3390/M239 - 25 May 2001

Viewed by 3834

Abstract

A mixture of Pd(acac)2 (41.26 mg, 0.12 mmol) and CuCl2 (168 mg, 1.25 mmol) [1] in 10 mL of 1,2-dimethoxyethan (DME) was stirred for 30 mn at 80°C under oxygen atmosphere, was added a -pinene (425 mg, 3.12 mmol).[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

118 KiB

Open AccessShort Note

Trans Acetic Acid 5-isopropyl-2-methyl Cyclohex-2-enyl Ester (Trans Carvyl Acetate)

by Badia Ait Allal, Larbi El Firdoussi, Smail Allaoud and Abdellah Karim

Molecules 2001, 6(12), M240; https://doi.org/10.3390/M240 - 25 May 2001

Viewed by 4066

Abstract

To a red solution of Li₂PdCl₄, prepared in situ by mixing LiCl (30.8 mg, 0.72 mmol) and PdCl₂ (43 mg, 0.24 mmol) in 20 mL of AcOH stirred at 85°C, was added Cu(OAc)₂ (4 g, 20 mmol) and stirred for 30 mn.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

101 KiB

Open AccessShort Note

3,5-Bis(trimethylsilyl)-4-chloropyridine

by A.J. Kay and A.D. Woolhouse

Molecules 2001, 6(12), M241; https://doi.org/10.3390/M241 - 20 Dec 2001

Cited by 1 | Viewed by 3531

Abstract

In connection with our studies of the nonlinear optical properties of pyridinylidene compounds we required some pyridine derivatives bearing bulky substituents at the 3- and 5-positions in addition to having an efficient leaving group at the 4-position.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

105 KiB

Open AccessShort Note

[3,5-Bis(trimethylsilyl)-1-methyl-4(1H)-pyridinylidene]-dicyanomethane

by A.J. Kay and A.D. Woolhouse

Molecules 2001, 6(12), M242; https://doi.org/10.3390/M242 - 20 Dec 2001

Viewed by 3688

Abstract

3,5-Bis(trimethylsilyl)-1-methyl-4-thiophenoxypyridinium iodide reacts with the anion of malononitrile to give the corresponding dicyanomethylidene-1,4-dihydropyridine.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

137 KiB

Open AccessShort Note

3-Ethoxycarbonyl-1,4-dihydro-2-methylquinoline

by Camara Hadietou Diadié, Attar Khalid, Boutayeb Mohammed, Benchidmi Mohamed and Essassi El Mokhtar

Molecules 2001, 6(12), M243; https://doi.org/10.3390/M243 - 20 Dec 2001

Viewed by 4413

Abstract

Compound 1 [1] (1.23 g, 4.94 mmol ) and 0.1 g of Pd/C (10%) in 50 ml of ethanol are introduced into an hydrogenation reactor.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

93 KiB

Open AccessShort Note

4-(Benzylthio)acetophenone

by Bruce A. Hathaway and Mary M. Triefenbach

Molecules 2001, 6(12), M244; https://doi.org/10.3390/M244 - 20 Dec 2001

Cited by 1 | Viewed by 3818

Abstract

During the course of our research on preparing parallel dipole-aligned crystals [1-2], we needed to prepare the previously unreported compound 4-benzyl-sulfonylacetophenone.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

115 KiB

Open AccessShort Note

4-Ferrocenylbenzoic Acid

by Ke-Qing Zhao, Ping Hu and Hong-Bo Xu

Molecules 2001, 6(12), M246; https://doi.org/10.3390/M246 - 20 Dec 2001

Cited by 18 | Viewed by 4761

Abstract

Ferrocene-containing liquid crystals, non-linear optical materials and magnetic materials are of considerable interests for their high thermal stability, tunable redox characteristics and structural variability [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

123 KiB

Open AccessShort Note

4-Formylphenyl 4-Ferrocenylbenzoate

by Ke-Qing Zhao, Ping Hu and Hong-Bo Xu

Molecules 2001, 6(12), M247; https://doi.org/10.3390/M247 - 20 Dec 2001

Cited by 3 | Viewed by 4283

Abstract

Ferrocene unit is comparatively large volume and it needs a longer molecular shape in geometry in to support the liquid crystal property [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

125 KiB

Open AccessShort Note

4-Hydroxyphenyl 4-Ferrocenylbenzoate

by Ke-Qing Zhao, Ping Hu and Hong-Bo Xu

Molecules 2001, 6(12), M248; https://doi.org/10.3390/M248 - 25 May 2001

Viewed by 4115

Abstract

The reaction of 4-ferrocenylbenzoyl chloride with 1,4-dihydroxybenzene gives 4-hydroxyphenyl 4-ferrocenylbenzoate, which contains a free hydroxyl group and it can be used for the synthesis of ester mono-substituted liquid crystal and hydrogen-bonded supra-molecular liquid crystals [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

114 KiB

Open AccessShort Note

4-Nitrophenylferrocene

by Ping Hu, Ke-Qing Zhao and Hong-Bo Xu

Molecules 2001, 6(12), M249; https://doi.org/10.3390/M249 - 20 Dec 2001

Cited by 29 | Viewed by 4200

Abstract

4-Nitrophenylferrocene is a candidate for the study of second order non-linear optical materials containing electron donating and electron withdrawing groups in the molecule.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

110 KiB

Open AccessShort Note

4-Ferrocenylaniline

by Hu Ping, Ke-Qing Zhao and Hong-Bo Xu

Molecules 2001, 6(12), M250; https://doi.org/10.3390/M250 - 20 Dec 2001

Cited by 21 | Viewed by 4393

Abstract

The reduction of 4-nitropheneylferrocene with tin in acidic condition gives 4-ferrocenylaniline, which is an important intermediate for the synthesis of ferrocene-containing Schiff's base liquid crystals [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

117 KiB

Open AccessShort Note

(4-hydroxybenzylidene)-4-ferrocenylaniline

by Ping Hu, Ke-Qing Zhao and Hong-Bo Xu

Molecules 2001, 6(12), M251; https://doi.org/10.3390/M251 - 20 Dec 2001

Cited by 10 | Viewed by 3720

Abstract

(4-Hydroxybenzylidene)-4-ferrocenylaniline has a free hydroxyl group and it can react with carboxylic acids to form esters and it is thus a key intermediate for the synthesis of mono-substituted ferrocenecontaining liquid crystal [1] with Schiff's base and ester group.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

123 KiB

Open AccessShort Note

(4-Formylbenzylidene)-4-ferrocenylaniline

by Ping Hu, Ke-Qing Zhao and Hong-Bo Xu

Molecules 2001, 6(12), M252; https://doi.org/10.3390/M252 - 20 Dec 2001

Cited by 1 | Viewed by 3598

Abstract

The reaction of 4-ferrocenylaniline with 1,4-benzenedicarboxaldehyde in an equimolar ratio in dilute solution, or with a large excess of the aniline, often gives the diimine product.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

107 KiB

Open AccessShort Note

Reduction of 5-Nitrosalicylic Acid in Water to Give 5-Amino-salicylic Acid*

by Gabriele Breviglieri, Bruno Giacomo, Contrini Sergio, Assanelli Cinzia, Eileen Campanab and Mauro Panunzio

Molecules 2001, 6(12), M260; https://doi.org/10.3390/M260 - 20 Dec 2001

Cited by 5 | Viewed by 8503

Abstract

In the course of a general programme aimed to find new protocols for environmentally friend chemistry [1-3] we were looking for a clean, high yielding method of reduction of 5-nitrosalicylic acid (1) to 5-aminosalicylic acid (5-ASA) in industrial scale [4].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

► Show Figures

Scheme 1

122 KiB

Open AccessShort Note

4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one

by Hussein F. Zohdi, Nora M. Rateb and A. Z. Haikal

Molecules 2001, 6(12), M261; https://doi.org/10.3390/M261 - 20 Dec 2001

Cited by 3 | Viewed by 4282

Abstract

To a cold solution of 5-trifluoromethyl-2,4-dihydropyrazol-3-one [1,2] (0.76 g, 5 mmol) in ethanol (25 ml) containing sodium acetate (0.82 g, 10 mol), 3-nitrobenzenediazonium chloride ( 5 mmol) was added dropwise with stirring at 0-5°C.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

163 KiB

Open AccessShort Note

2-(2`,3`,5`-Tri-O-acetyl-b-D-ribofuranosyl)-4-(3-nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one

by Abdelfattah Haikal, Hussein F. Zohdi and Shaikha El-Neyadi

Molecules 2001, 6(12), M262; https://doi.org/10.3390/M262 - 20 Dec 2001

Cited by 1 | Viewed by 4292

Abstract

To a solution of 4-(3-nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one 1 [1] (0.903 g, 3 mmol) in hexamethyldisilazine (HMDS) (25 ml) was added few crystals of anhydrous ammonium sulfate [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

141 KiB

Open AccessShort Note

2-(b-D-Ribofuranosyl)-4-(3-nitrophenylazo)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

by Hussein F. Zohdi and Abdelfattah Haikal

Molecules 2001, 6(12), M263; https://doi.org/10.3390/M263 - 20 Dec 2001

Cited by 2 | Viewed by 3994

Abstract

The desired compound 2 was obtained by complete deprotection of the acetylated nucleoside 1 [1] using triethylamine [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

132 KiB

Open AccessShort Note

6-Amino-1-(2’-deoxy-b-D-ribofuranosyl)-4,5-dihydro-8H-imidazo[4,5-e][1,3]diazepine-4,8-dione

by Ramesh K. Sood, Vishweshwar S. Bhadti, Huan-Ming Chen and Ramachandra S. Hosmane

Molecules 2001, 6(12), M264; https://doi.org/10.3390/M264 - 20 Dec 2001

Viewed by 4737

Abstract

The starting methyl 1-(2’-deoxy-b-D-ribofuranosyl)imidazole-4,5-dicarboxylate (1) was prepared by deoxygenation of the corresponding riboside, employing the literature procedure [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

103 KiB

Open AccessShort Note

3,5-Bis(trimethylsilyl)-1-methyl-4-thiophenoxypyridinium Iodide

by A.J. Kay and A.D. Woolhouse

Molecules 2001, 6(12), M265; https://doi.org/10.3390/M265 - 20 Dec 2001

Cited by 1 | Viewed by 3486

Abstract

3,5-Bis(trimethylsilyl)-4-thiophenoxypyridine is readily converted to its pyridinium methiodide.[...] Full article

100 KiB

Open AccessShort Note

3,5-Bis(trimethylsilyl)-4-thiophenoxypyridine

by A.J. Kay and A.D. Woolhouse

Molecules 2001, 6(12), M266; https://doi.org/10.3390/M266 - 20 Dec 2001

Cited by 2 | Viewed by 3478

Abstract

Reaction of 3,5-bis(trimethylsilyl)-4-chloropyridine [1] with thiophenol gave 3,5-bis(trimethylsilyl)-4-thiophenoxypyridine, a potential precursor to novel pyridinylidene derived nonlinear optical materials.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

140 KiB

Open AccessShort Note

3-(4’-Methyl-3’-oxocyclohex-1’-enyl)butyric Acid Methyl Ester

by Soufiane El Houssame, Larbi El Firdoussi and Abdellah Karim

Molecules 2001, 6(12), M267; https://doi.org/10.3390/M267 - 20 Dec 2001

Viewed by 3843

Abstract

The alkoxycarbonylation of terpenic olefins which affords the corresponding esters is an elegant synthesis [1-2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

13 KiB

Open AccessShort Note

(4-Isopropenyl-cyclohex-1-enyl)acetic Acid Ethylester

by Soufiane El Houssame, Larbi El Firdoussi and Abdellah Karim

Molecules 2001, 6(12), M268; https://doi.org/10.3390/M268 - 20 Dec 2001

Viewed by 4148

Abstract

The carbonylation of allylic componds catalyzed by transition metal complexes under atmospheric pressure of CO is one of the most attractive tools to synthesize the b ,g - unsaturated carbonyl compounds, which are versatile building blocks [1-2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

90 KiB

Open AccessShort Note

2-Cinnamyl-1,3-oxazole-4-carboxaldehyde p-Toluenesulfonyl Hydrazone

by Fahim Ahmed

Molecules 2001, 6(12), M269; https://doi.org/10.3390/M269 - 20 Dec 2001

Cited by 1 | Viewed by 3954

Abstract

To a stirred solution of p-toluenesulfonhydrazide (0.61g, 3.3 mmol) in methanol/water (6:4, 20 ml) at 60°C was added 2-cinnamyl-1,3-oxazole-4-carboxaldehyde [1](0.50 g, 2.5 mmol).[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

85 KiB

Open AccessShort Note

2-(2'-Cinnamyl-1',3'-oxazolyl)-1,3-dithiolane

by Fahim Ahmed

Molecules 2001, 6(12), M270; https://doi.org/10.3390/M270 - 20 Dec 2001

Viewed by 3579

Abstract

To a mixture of 2-cinnamyl-1,3-oxazole-4-carboxaldehyde [1,2] (2.8 g, 14 mmol) and ethanedithiol (2.3 g, 21 mmol) in methylene chloride (100 ml) was added boron trifluoride etherate (2.8 g, 21 mmol).[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

114 KiB

Open AccessShort Note

6-Methyl-1,3-diphenylpyrazolo[3,4-d]oxazin-4-one

by Mohammadine El Haddad and Mohamed Akssira

Molecules 2001, 6(12), M271; https://doi.org/10.3390/M271 - 20 Dec 2001

Cited by 2 | Viewed by 4524

Abstract

b-Pyrazolic amino acid [1] (2 mmoles) was dissolved in acetic anhydride [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

114 KiB

Open AccessShort Note

5-Methyl-1,3-diphenylpyrazolo[4,3-d]oxazin-7-one

by Mohammadine El Haddad and Mohamed Akssira

Molecules 2001, 6(12), M272; https://doi.org/10.3390/M272 - 20 Dec 2001

Viewed by 4220

Abstract

In a similar manner to the reported procedure [1,2], b-pyrazolic amino acid [3] (2 mmoles) was dissolved in acetic anhydride.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

5-Phenyl-3-[1-(phenylsulphonyl)-hexyl]-1,2,4-triazine

by Danuta Branowska, Stanislaw Ostrowski and Andrzej Rykowski

Molecules 2001, 6(12), M273; https://doi.org/10.3390/M273 - 20 Dec 2001

Viewed by 3479

Abstract

As part of ongoing research programme we synthesised the title compound as valuable intermediate for intermolecular cycloaddition reactions, leading to biologically active heterocycles.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

97 KiB

Open AccessShort Note

(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol (Norsanguinine)

by Matthias Treu and Ulrich Jordis

Molecules 2001, 6(12), M274; https://doi.org/10.3390/M274 - 20 Dec 2001

Cited by 2 | Viewed by 3710

Abstract

Norsanguinine (2) is an alkaloid isolated from the bulbs of L. sanguinea [1] and synthesized as racemate by Kita [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

112 KiB

Open AccessShort Note

Tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate

by Gilles Olive and Alain Jacques

Molecules 2001, 6(12), M275; https://doi.org/10.3390/M275 - 20 Dec 2001

Cited by 2 | Viewed by 4224

Abstract

The synthesis of the title compound is already described [1, 2] and we report here the fully optimized procedure.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

27 KiB

Open AccessArticle

An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

by Matthias Treu, Ulrich Jordis and Ving J. Lee

Molecules 2001, 6(12), 959-963; https://doi.org/10.3390/61200959 - 30 Nov 2001

Cited by 9 | Viewed by 5818

Abstract

An improved procedure for the synthesis an analog of the p38 inhibitor compound VX- 745 is reported. Full article

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Figure 1

61 KiB

Open AccessArticle

Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH₄Cl Solution

by Artur Jõgi and Uno Mäeorg

Molecules 2001, 6(12), 964-968; https://doi.org/10.3390/61200964 - 30 Nov 2001

Cited by 35 | Viewed by 11418

Abstract

The reaction of substituted and unsubstituted propargylic bromides with butanal in presence of zinc power in THF/saturated aqueous NH₄Cl solution gave corresponding allenic and propargylic alcohols with high selectivity. Full article

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Figure 1

51 KiB

Open AccessArticle

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles

by Odd R. Gautun and Per H.J. Carlsen

Molecules 2001, 6(12), 969-978; https://doi.org/10.3390/61200969 - 30 Nov 2001

Cited by 10 | Viewed by 7520

Abstract

The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles. This lends support to a proposed mechanism for the rearrangement that involves consecutive nucleophilic displacements steps. Full article

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Figure 1

49 KiB

Open AccessArticle

Synthesis of Novel Diammonium Gemini Surfactants

by Øystein Rist, Anita Rike, Liv Ljones and Per H.J. Carlsen

Molecules 2001, 6(12), 979-987; https://doi.org/10.3390/61200979 - 30 Nov 2001

Cited by 23 | Viewed by 8125

Abstract

Selective synthesis of linear and gemini quaternary ammonium surfactants was accomplished by reacting the corresponding alkyl alcohols with 2-chloro-N,N-dimethylethylamine under basic conditions. The amines were quaternized with methyl chloride or methyl iodide. Full article

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Figure 1

49 KiB

Open AccessArticle

Novel Chiral Switching Ligands for Enantioselective Asymmetric Reductions of Prochiral Ketones

by S. Narasimhan, S. Swarnalakshmi, R. Balakumar and S. Velmathi

Molecules 2001, 6(12), 988-995; https://doi.org/10.3390/61200988 - 30 Nov 2001

Cited by 13 | Viewed by 6403

Abstract

The newly developed chiral ligands 1 and 4 show opposite enantioselectivity in the asymmetric reduction of prochiral ketones resulting in the production of either enantiomer depending on the metal complex with high enantiomeric excess. Full article

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Figure 1

25 KiB

Open AccessArticle

Bi(TFA)₃ and Bi(OTf)₃ Catalyzed Conversions of Epoxides to Thiiranes with Ammonium Thiocyanate and Thiourea under Non-Aqueous Conditions

by Iraj Mohammadpoor-Baltork and Ahmad R. Khosropour

Molecules 2001, 6(12), 996-1000; https://doi.org/10.3390/61200996 - 30 Nov 2001

Cited by 33 | Viewed by 7681

Abstract

Various epoxides are converted to their corresponding thiiranes in excellent yields with ammonium thiocyanate and thiourea under non-aqueous conditions in the presence of catalytic amounts of Bi(TFA)₃ and Bi(OTf)₃. Full article

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Figure 1

117 KiB

Open AccessArticle

Facile Synthesis of 1,6-Bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane: a New Dinucleating Ligand

by Gang-Chun Sun, Zhan-Hang He, Zhong-Jun Li, Xiao-Dong Yuan, Zhi-Juan Yang, Guo-Xi Wang, Liu-Fang Wang and Chang-Rang Liu

Molecules 2001, 6(12), 1001-1005; https://doi.org/10.3390/61201001 - 30 Nov 2001

Cited by 10 | Viewed by 9637

Abstract

A convenient three-step preparation of the dinucleating ligand, 1,6-bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane (3) starting from 2,6-bis(hydroxymethyl)-4-methylphenol (4) is reported. Compound 4 was partially oxidized with preactivated manganese dioxide to form compound 5, which was converted to 2-hydroxy-3-chloromethyl-5-ethylbenzaldehyde (6) with conc.HCl/EtOH. Compound 6 in turn reacted with [...] Read more.

A convenient three-step preparation of the dinucleating ligand, 1,6-bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane (3) starting from 2,6-bis(hydroxymethyl)-4-methylphenol (4) is reported. Compound 4 was partially oxidized with preactivated manganese dioxide to form compound 5, which was converted to 2-hydroxy-3-chloromethyl-5-ethylbenzaldehyde (6) with conc.HCl/EtOH. Compound 6 in turn reacted with N,N’-bis (2-furyl)-1,2-diaminoethane (7) in the presence of K₂CO₃in ethanol to give the title compound 3. No protecting groups were required in the whole process and the conditions were mild. Full article

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Figure 1

29 KiB

Open AccessArticle

Efficient Deprotection of Phenol Methoxymethyl Ethers Using a Solid Acid Catalyst with Wells-Dawson Structure

by G. Romanelli, J. C. Autino, G. Baronetti and H. Thomas

Molecules 2001, 6(12), 1006-1011; https://doi.org/10.3390/61201006 - 30 Nov 2001

Cited by 26 | Viewed by 12327

Abstract

Deprotection of various phenols from their respective methoxymethyl ethers using an heteropolyacid catalyst was studied. The catalyst was the Wells-Dawson heteropolyacid, used both in bulk or supported on silica. Yields were high to quantitative after less than one hour reaction time and the [...] Read more.

Deprotection of various phenols from their respective methoxymethyl ethers using an heteropolyacid catalyst was studied. The catalyst was the Wells-Dawson heteropolyacid, used both in bulk or supported on silica. Yields were high to quantitative after less than one hour reaction time and the catalyst was easily recoverable and reusable. Full article

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Review

Jump to: Research, Other

223 KiB

Open AccessReview

Some Heteroaromatic Organomercurials, Their Syntheses and Reactions: A Review of Our Research (1980-2000)

by Lech Skulski and Piotr Wroczynski

Molecules 2001, 6(12), 927-958; https://doi.org/10.3390/61200927 - 30 Nov 2001

Cited by 5 | Viewed by 9791

Abstract

This review reports some novel (or improved) synthetic methods for preparing a number of aromatic (carbocyclic and predominantly heterocyclic) organomercurials, particularly those derived from theophylline, theobromine and uracil, as well as some novel halo- and cyano-demercuration reactions. We have also synthesized the [...] Read more.

This review reports some novel (or improved) synthetic methods for preparing a number of aromatic (carbocyclic and predominantly heterocyclic) organomercurials, particularly those derived from theophylline, theobromine and uracil, as well as some novel halo- and cyano-demercuration reactions. We have also synthesized the first stable organic derivative of mercury(I), viz. 1,8-bis(acetoxydimercurio) theobromine, and studied its novel reactions. We have also improved the old Willgerodt method (1897), applicable for preparing various diaryliodonium chlorides from appropriate (dichloroiodo)arenes and symmetric aromatic mercurials. A full list of our works, published over the past twenty years (1980-2000), is also provided (see Refs. 1-16). Full article

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Figure 1

Other

Jump to: Research, Review

9 KiB

Open AccessNew Book Received

Asymmetric Catalysis In Organic Synthesis

by Ryoji Nagoya

Molecules 2001, 6(12), 1012; https://doi.org/10.3390/61201012 - 31 Dec 2001

Cited by 1 | Viewed by 4658

Abstract

The author Ryoji Nagoya shared the Nobel Prize in Chemistry for 2001.[...] Full article

9 KiB

Open AccessNew Book Received

Catalytic Asymmetric Synthesis, 2nd Edition

by Shu-Kun Lin

Molecules 2001, 6(12), 1013-1014; https://doi.org/10.3390/61201013 - 31 Dec 2001

Cited by 1 | Viewed by 4243

Abstract

The field of catalytic asymmetric synthesis has grown immensely since the first edition was published in 1993, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields--from medicine to materials science.[...] Full article

9 KiB

Open AccessNew Book Received

Advanced Organic Chemistry. Part B: Reactions and Synthesis. Fourth Edition

by Francis A. Carey and Richard J. Sundberg

Molecules 2001, 6(12), 1015-1016; https://doi.org/10.3390/61201015 - 31 Dec 2001

Cited by 4 | Viewed by 9005

Abstract

The control of reactivity to achieve specific syntheses is one of the overarching goals of organic chemistry.[...] Full article

19 KiB

Open AccessNew Book Received

Molecular Switches

by Shu-Kun Lin

Molecules 2001, 6(12), 1017-1018; https://doi.org/10.3390/61201017 - 31 Dec 2001

Viewed by 4024

Abstract

“This book will appeal most to organic chemists, because of the way new structures are introduced through their synthesis, but it will also provide a useful introduction for other scientists, provided they are conversant with molecular structures.”(Perkin Transactions, No.19, 2001)[...] Full article

19 KiB

Open AccessNew Book Received

The Biotechnology of Ethanol: Classical and Future Applications

by Shu-Kun Lin

Molecules 2001, 6(12), 1019-1020; https://doi.org/10.3390/61201019 - 31 Dec 2001

Cited by 3 | Viewed by 4735

Abstract

Focusing on the biotechnology of ethanol, this book highlights its industrial relevance as one of the most important products of primary metabolism.[...] Full article

8 KiB

Open AccessNew Book Received

Marketing and Sales in the Chemical Industry

by Shu-Kun Lin

Molecules 2001, 6(12), 1021; https://doi.org/10.3390/61201021 - 31 Dec 2001

Cited by 1 | Viewed by 4576

Abstract

*Editor's Note: The brief summary and the contents of the books are reported as provided by the author or the publishers. Authors and publishers are encouraged to send review copies of their recent books of potential interest to readers of Molecules [...] Read more.

*Editor's Note: The brief summary and the contents of the books are reported as provided by the author or the publishers. Authors and publishers are encouraged to send review copies of their recent books of potential interest to readers of Molecules to the Editor-in-Chief (Dr. Shu-Kun Lin, MDPI, Saengergasse 25, CH-4054 Basel, Switzerland. Tel. +41 79 322 3379, Fax +41 61 302 8918, E-mail: [email protected]).[...] Full article

29 KiB

Open AccessNew Book Received

New Trends in Synthetic Medicinal Chemistry. (Methods and Principles in Medicinal Chemistry, Volume 7)

by Shu-Kun Lin

Molecules 2001, 6(12), 1022-1029; https://doi.org/10.3390/61201022 - 31 Dec 2001

Viewed by 4266

Abstract

The long-awaited volume on synthetic chemistry in the series "Methods and Principles in Medicinal Chemistry" is now available.[...] Full article

25 KiB

Open AccessNew Book Received

Perspectives in Nucleoside and Nucleic Acid Chemistry

by Shu-Kun Lin and Helmut Rosemeyer

Molecules 2001, 6(12), 1030-1033; https://doi.org/10.3390/61201030 - 31 Dec 2001

Cited by 1 | Viewed by 4325

Abstract

The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleosideand nucleotide-based antiviral and antitumor drugs.[...] Full article

29 KiB

Open AccessNew Book Received

Chemistry for the 21st Century

by Shu-Kun Lin and Israel Schechter

Molecules 2001, 6(12), 1034-1040; https://doi.org/10.3390/61201034 - 31 Dec 2001

Viewed by 4199

Abstract

Here, numerous winners of the Wolf prize from all chemical disciplines provide an overview of the new ideas and approaches that will shape this dynamic science over the forthcoming decades and so will have a decisive influence on our living conditions.[...] Full article

16 KiB

Open AccessNew Book Received

The Structure of the Nucleon

by Shu-Kun Lin and Wolfram Weise

Molecules 2001, 6(12), 1041-1043; https://doi.org/10.3390/61201041 - 31 Dec 2001

Cited by 1 | Viewed by 4236

Abstract

As the only stable baryon, the nucleon is of crucial importance in particle physics.[...] Full article

20 KiB

Open AccessNew Book Received

Industrial Biotransformations

by Shu-Kun Lin, Karsten Seelbach and Christian Wandrey

Molecules 2001, 6(12), 1044-1046; https://doi.org/10.3390/61201044 - 31 Dec 2001

Cited by 2 | Viewed by 4635

Abstract

Industrial Biotransformations - a user-friendly and application-oriented up-to-date overview of one-step biotransformations of industrial importance.[...] Full article

28 KiB

Open AccessNew Book Received

Organic Synthesis on Solid Phase. (Supports, Linkers, Reactions)

by Shu-Kun Lin

Molecules 2001, 6(12), 1047-1054; https://doi.org/10.3390/61201047 - 31 Dec 2001

Cited by 1 | Viewed by 4075

Abstract

Organic synthesis on solid supports is a rapidly developing methodology, which offers several advantages if compared to traditional synthesis in solution.[...] Full article

49 KiB

Open AccessNew Book Received

Liquid Crystals :Experimental Study of Physical Properties and Phase Transitions

by Satyendra Kumar

Molecules 2001, 6(12), 1055-1056; https://doi.org/10.3390/61201055 - 31 Dec 2001

Cited by 23 | Viewed by 7504

Abstract

This book describes in detail various experimental techniques used in the study of liquid crystals.[...] Full article

26 KiB

Open AccessNew Book Received

Shape and Structure, from Engineering to Nature

by Shu-Kun Lin

Molecules 2001, 6(12), 1057-1058; https://doi.org/10.3390/61201057 - 31 Dec 2001

Cited by 1 | Viewed by 4992

Abstract

Seemingly universal geometric forms unite the flow systems of engineering and nature.[...] Full article

9 KiB

Open AccessNew Book Received

Statistics in Genetics and in the Environmental Sciences. (Trends in Mathematics)

by L. T. Fernholz, S. Morgenthaler and W. Stahel

Molecules 2001, 6(12), 1059; https://doi.org/10.3390/61201059 - 31 Dec 2001

Viewed by 5205

Abstract

This book grew out of a workshop on statistics in the sciences held on Monte Verità, Switzerland, in the spring of 1999.[...] Full article

8 KiB

Open AccessNew Book Received

Progress in Drug Research

by E. Jucker

Molecules 2001, 6(12), 1060; https://doi.org/10.3390/61201060 - 31 Dec 2001

Viewed by 4012

Abstract

*Editor's Note: The brief summary and the contents of the books are reported as provided by the author or the publishers.[...] Full article

10 KiB

Open AccessNew Book Received

Antiviral Agents: Advances and Problems. Progress in Drug Research

by E. Jucker

Molecules 2001, 6(12), 1061-1062; https://doi.org/10.3390/61201061 - 31 Dec 2001

Viewed by 4290

Abstract

This first Special Volume of the monograph series "Progress in Drug Research" is a compilation of most topical and concise reviews on virus research and drug development.[...] Full article

9 KiB

Open AccessNew Book Received

Recombinant Protein Drugs.( Milestones in Drug Therapy)

by P. Buckel

Molecules 2001, 6(12), 1063; https://doi.org/10.3390/61201063 - 31 Dec 2001

Cited by 1 | Viewed by 5070

Abstract

Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products.[...] Full article

22 KiB

Open AccessNew Book Received

March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 5th Edition

by Shu-kun Lin and Jerry March

Molecules 2001, 6(12), 1064-1065; https://doi.org/10.3390/61201064 - 31 Dec 2001

Cited by 16 | Viewed by 11530

Abstract

"...the book remains tremendous value for money...more pages per buck than most other texts...so it will remain a firm favourite as a general organic text and an easy-to-use 1-volume reference...will undoubtedly appear in all organic chemistry libraries and probably on many chemists’ personal [...] Read more.

"...the book remains tremendous value for money...more pages per buck than most other texts...so it will remain a firm favourite as a general organic text and an easy-to-use 1-volume reference...will undoubtedly appear in all organic chemistry libraries and probably on many chemists’ personal bookshelves too."[...] Full article

24 KiB

Open AccessNew Book Received

Grundlagen der Life Sciences: Chemie - Biologie - Energetik

by Shu-Kun Lin

Molecules 2001, 6(12), 1066-1067; https://doi.org/10.3390/61201066 - 31 Dec 2001

Viewed by 4066

Abstract

Der Begriff Life Sciences hat in den letzten Jahren immer mehr an Bedeutung gewonnen.[...] Full article

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Molecules, Volume 6, Issue 12 (December 2001) – 65 articles , Pages 927-1067, Articles M232-M275

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