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Molecules, Volume 7, Issue 4 (April 2002), Pages 374-411

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Research

Open AccessArticle 4a,5,9,10,11,12-Hexahydro-6H-benzo[a]cyclohepta[hi]benzofuran - Synthesis of Unnatural Galanthamine Analogs
Molecules 2002, 7(4), 374-381; doi:10.3390/70400374
Received: 11 November 2001 / Revised: 29 April 2002 / Accepted: 30 April 2002 / Published: 30 April 2002
Cited by 2 | PDF Full-text (44 KB) | HTML Full-text | XML Full-text
Abstract The synthesis of an unnatural galanthamine analog is reported Full article
Open AccessArticle Synthesis of New Active Sulfones in the 5-Nitroimidazole Series
Molecules 2002, 7(4), 382-385; doi:10.3390/70400382
Received: 29 March 2002 / Revised: 30 April 2002 / Accepted: 30 April 2002 / Published: 30 April 2002
Cited by 4 | PDF Full-text (26 KB) | HTML Full-text | XML Full-text
Abstract We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology. Full article
Open AccessArticle Synthesis of Mixed Carbonates via a Three-Component Coupling of Alcohols, CO2, and Alkyl Halides in the Presence of K2CO3 and Tetrabutylammonium Iodide
Molecules 2002, 7(4), 386-393; doi:10.3390/70400386
Received: 24 October 2001 / Revised: 29 April 2002 / Accepted: 30 April 2002 / Published: 30 April 2002
Cited by 8 | PDF Full-text (39 KB) | HTML Full-text | XML Full-text
Abstract Various mixed carbonates can be conveniently prepared in good yields using the corresponding alcohols, alkyl halides under CO2 atmosphere in the presence of potassium carbonate or sodium carbonate and tetrabutylammonium iodide. Full article
Open AccessArticle Synthesis of New Lipophilic Phosphonate and Phosphonamidate Analogues of N-Acetylmuramyl-L-alanyl-D-isoglutamine Related to LK 423
Molecules 2002, 7(4), 394-404; doi:10.3390/70400394
Received: 9 January 2002 / Revised: 2 May 2002 / Accepted: 2 May 2002 / Published: 2 May 2002
Cited by 5 | PDF Full-text (104 KB) | HTML Full-text | XML Full-text
Abstract
A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between Lalanine and D-glutamic acid [...] Read more.
A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between Lalanine and D-glutamic acid (or D-isoglutamine), yielding new MDP analogues 5 and 9. Furthermore, the amide bond between L-Ala and D-Glu was replaced by a phosphonate isostere, giving peptidyl phosphonate 14. The scope and limitations of the synthetic strategies employed are discussed. Full article
Open AccessArticle Synthesis of Platinum Complexes from N-Benzyl-1,3-Propanediamine Derivatives, Potential Antineoplastic Agents
Molecules 2002, 7(4), 405-411; doi:10.3390/70400405
Received: 17 August 2001 / Revised: 8 April 2002 / Accepted: 30 April 2002 / Published: 30 April 2002
Cited by 6 | PDF Full-text (38 KB) | HTML Full-text | XML Full-text
Abstract This work describes the synthesis of seven new platinum complexes having Nbenzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K2[PtCl4] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents. Full article

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