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Molecules, Volume 7, Issue 6 (June 2002) – 5 articles , Pages 469-506

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Research

33 KiB  
Article
Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
by Nuria Aguilar and Jochen Krüger
Molecules 2002, 7(6), 469-474; https://doi.org/10.3390/70600469 - 30 Jun 2002
Cited by 8 | Viewed by 7222
Abstract
The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid [...] Read more.
The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product. Full article
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87 KiB  
Article
Synthetic Studies on Diels-Alder Adducts: Intramolecular Interactions Between Two Functions
by Mauricio Gomes Constantino, Altamiro Xavier De Souza and Gil Valdo José Da Silva
Molecules 2002, 7(6), 475-486; https://doi.org/10.3390/70600475 - 30 Jun 2002
Cited by 2 | Viewed by 9096
Abstract
In this paper we describe the synthesis of a γ,δ-unsaturated aldehyde from a bicyclic Diels-Alder adduct, to be used in future electrocyclic reaction studies. A number of reactions produced undesired materials resulting from the interaction between functions, forcing the use of partial protection [...] Read more.
In this paper we describe the synthesis of a γ,δ-unsaturated aldehyde from a bicyclic Diels-Alder adduct, to be used in future electrocyclic reaction studies. A number of reactions produced undesired materials resulting from the interaction between functions, forcing the use of partial protection to accomplish a synthesis that would be otherwise straightforward. Suggestions to account for the results are given. Full article
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50 KiB  
Article
An Efficient Preparation of 1,2-Diamino-1-phenylheptane
by S. Thennarasu and P. T. Perumal
Molecules 2002, 7(6), 487-493; https://doi.org/10.3390/70600487 - 30 Jun 2002
Cited by 11 | Viewed by 7755
Abstract
A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is [...] Read more.
A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time. Full article
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117 KiB  
Article
A Novel Synthesis of 1,2,4-Triazolopteridines
by Tayseer A. Abdallah, Manal A. Darwish and Hamdi M. Hassaneen
Molecules 2002, 7(6), 494-500; https://doi.org/10.3390/70600494 - 30 Jun 2002
Cited by 20 | Viewed by 6762
Abstract
Reaction of 1,2-dihydro-2-thioxopteridin-4(3H)-one, 6,7-dimethyl-1,2-dihydro-2-thioxopteridin-4(3H)-one and 6,7-diphenyl-1,2-dihydro-2-thioxopteridin-4(3H)-one with hydrazonoyl halides affords the title compounds in good yields. Full article
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34 KiB  
Article
Carotamine, a Unique Aromatic Amide from Daucus Carota L. Var Biossieri (Apiaceae)
by Omayma A. Eldahshan, Nahla A. Ayoub, Abd-El Naser B. Singab and Mohamed M. El-Azizi
Molecules 2002, 7(6), 501-506; https://doi.org/10.3390/70600501 - 30 Jun 2002
Cited by 2 | Viewed by 8899
Abstract
The unique aromatic peptide 4-(p-aminobenzoylamino)-2-aminobenzoic acid, carotamine, together with 2,4-diaminobenzoic acid, isolated for the first time from a plant source, were identified from the aqueous alcoholic extract of the aerial parts of Daucus carota L. var. boissieri (Apiaceae). The structures were determined through [...] Read more.
The unique aromatic peptide 4-(p-aminobenzoylamino)-2-aminobenzoic acid, carotamine, together with 2,4-diaminobenzoic acid, isolated for the first time from a plant source, were identified from the aqueous alcoholic extract of the aerial parts of Daucus carota L. var. boissieri (Apiaceae). The structures were determined through conventional methods of analysis and confirmed by LC-ESI/MS and NMR spectral analysis. Full article
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