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Int. J. Mol. Sci. 2012, 13(1), 477-490; doi:10.3390/ijms13010477

Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity

Institute of Entomology, Metropolitan University of Educational Sciences, Avenue J.P. Alessandri 774 Ñuñoa, Código Postal 7760197, Santiago, Chile
Received: 23 November 2011 / Revised: 22 December 2011 / Accepted: 23 December 2011 / Published: 4 January 2012
(This article belongs to the Special Issue Non-Coding RNAs)
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The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and genes. ncRNAs are also becoming central for understanding gene expression and silencing. Indeed, before the discovery of ncRNAs, proteins were viewed as the major molecules in the regulation of gene expression and gene silencing; however, recent findings suggest that ncRNA also plays an important role in gene expression. Reverse transcription of RNA viruses and their integration into the genome of eukaryotes and also their relationship with the ncRNA suggest that their origin is basal in genome evolution, and also probably constitute the first mechanism of gene regulation. I am to review the different roles of ncRNAs in the framework of gene evolution, as well as the importance of ncRNAs and viruses in the epigenesis and in the non-Mendelian model of heredity and evolution. View Full-Text
Keywords: non-coding RNAs; epigenesis; imprinting; RNA viruses; coevolution non-coding RNAs; epigenesis; imprinting; RNA viruses; coevolution

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Frías-Lasserre, D. Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity. Int. J. Mol. Sci. 2012, 13, 477-490.

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