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Int. J. Mol. Sci. 2012, 13(11), 14698-14706; doi:10.3390/ijms131114698

Non-Alcoholic Fatty Liver Disease Is not Related to the Incidence of Diabetic Nephropathy in Type 2 Diabetes

1
Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2
Department of Gastroenterology, Beijing Chaoyang Hospital Jingxi Campus, Capital Medical University, Beijing 100430, China
3
Department of Clinic Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
4
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 29 August 2012 / Revised: 16 October 2012 / Accepted: 1 November 2012 / Published: 12 November 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

To analyze the association between non-alcoholic fatty liver disease (NAFLD) and the incidence of diabetic nephropathy in patients with type 2 diabetes, the incidence of diabetic nephropathy was assessed in 413 type 2 diabetic patients, by testing the 24 h urinary albumin excretion rate (UAER). The NAFLD was diagnosed based on patient’s medical history and liver ultrasound. The difference in diabetic nephropathy incidence between patients with and without NAFLD was tested by χ2. Multivariate logistic regression analysis was used to assess the factors associated with diabetic nephropathy among type 2 diabetic patients. Total 363 out of 413 type 2 diabetic patients were enrolled in this study. The incidences of NAFLD and diabetic nephropathy in participants were approximately 56% (202/363) and 38% (137/363) respectively, and there was no significant difference in the prevalence of diabetic nephropathy between patients with and without NAFLD (37.1% vs. 38.5%, p = 0.787). The duration of diabetes (odds ratio [OR] 1.065, 95% confidence interval [CI] 1.014–1.120, p = 0.012), waist circumference (OR 1.077, 95% CI 1.040–1.116, p = 0.000), and fasting blood glucose (FBG; OR 1.136, 95% CI 1.023–1.1262, p = 0.017) were significantly associated with diabetic nephropathy, whereas sex, high blood pressure, total cholesterol (TC), triglyceride (TG), and ankle brachial pressure index (ABI) were not significantly associated with the disorder. The present results suggest that NAFLD is not related to the incidence of diabetic nephropathy in type 2 diabetes, but the duration of diabetes, waist circumference, and FBG are important factors for diabetic nephropathy in type 2 diabetes. View Full-Text
Keywords: non-alcoholic fatty liver disease; diabetic nephropathy; diabetes non-alcoholic fatty liver disease; diabetic nephropathy; diabetes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhan, Y.-T.; Zhang, C.; Li, L.; Bi, C.-S.; Song, X.; Zhang, S.-T. Non-Alcoholic Fatty Liver Disease Is not Related to the Incidence of Diabetic Nephropathy in Type 2 Diabetes. Int. J. Mol. Sci. 2012, 13, 14698-14706.

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