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Int. J. Mol. Sci. 2012, 13(6), 6679-6697; doi:10.3390/ijms13066679

Intravascular Targets for Molecular Contrast-Enhanced Ultrasound Imaging

1,* , 1
1 MI Lab, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim N-7006, Norway 2 Department of Medical Technology, SINTEF Technology and Society, Trondheim N-7491, Norway
* Author to whom correspondence should be addressed.
Received: 19 April 2012 / Revised: 21 May 2012 / Accepted: 22 May 2012 / Published: 1 June 2012
(This article belongs to the Special Issue Advances in Molecular Oncology (special issue))
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Molecular targeting of contrast agents for ultrasound imaging is emerging as a new medical imaging modality. It combines advances in ultrasound technology with principles of molecular imaging, thereby allowing non-invasive assessment of biological processes in vivo. Preclinical studies have shown that microbubbles, which provide contrast during ultrasound imaging, can be targeted to specific molecular markers. These microbubbles accumulate in tissue with target (over) expression, thereby significantly increasing the ultrasound signal. This concept offers safe and low-cost imaging with high spatial resolution and sensitivity. It is therefore considered to have great potential in cancer imaging, and early-phase clinical trials are ongoing. In this review, we summarize the current literature on targets that have been successfully imaged in preclinical models using molecularly targeted ultrasound contrast agents. Based on preclinical experience, we discuss the potential clinical utility of targeted microbubbles.
Keywords: ultrasound imaging; targeted contrast agents; angiogenesis; molecular imaging; microbubbles; cancer ultrasound imaging; targeted contrast agents; angiogenesis; molecular imaging; microbubbles; cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Moestue, S.A.; Gribbestad, I.S.; Hansen, R. Intravascular Targets for Molecular Contrast-Enhanced Ultrasound Imaging. Int. J. Mol. Sci. 2012, 13, 6679-6697.

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