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2013-01-11T21:42:27+08:00
2013-01-11T13:45:05+08:00
Microsoft® Office Word 2007
Microsoft® Office Word 2007
silicon quantum dot; alminoprofen; cyclooxygenase-2; cytotoxicity and biological effect
application/pdf
Evaluation of Anti-Inflammatory Drug-Conjugated Silicon Quantum Dots: Their Cytotoxicity and Biological Effect
Sanshiro Hanada 1
*
Kouki Fujioka 2
Yasuhiro Futamura 1
Noriyoshi Manabe 1
Akiyoshi Hoshino 1 and Kenji Yamamoto 1
Silicon quantum dots (Si-QDs) have great potential for biomedical applications, including their use as biological fluorescent markers and carriers for drug delivery systems. Biologically inert Si-QDs are less toxic than conventional cadmium-based QDs, and can modify the surface of the Si-QD with covalent bond. We synthesized water-soluble alminoprofen-conjugated Si-QDs (Ap-Si). Alminoprofen is a non-steroid anti-inflammatory drug (NSAID) used as an analgesic for rheumatism. Our results showed that the “silicon drug” is less toxic than the control Si-QD and the original drug. These phenomena indicate that the condensed surface integration of ligand/receptor-type drugs might reduce the adverse interaction between the cells and drug molecules. In addition, the medicinal effect of the Si-QDs (i.e., the inhibition of COX-2 enzyme) was maintained compared to that of the original drug. The same drug effect is related to the integration ratio of original drugs, which might control the binding interaction between COX-2 and the silicon drug. We conclude that drug conjugation with biocompatible Si-QDs is a potential method for functional pharmaceutical drug development.
silicon quantum dot
alminoprofen
cyclooxygenase-2
cytotoxicity and biological effect
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