Non-Coding RNAs in Muscle Dystrophies
AbstractncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches. Important data come from the field of hereditary muscle dystrophies, like Duchenne muscle dystrophy and Myotonic dystrophies, rare diseases affecting 1 in 7000–15,000 newborns and is characterized by severe to mild muscle weakness associated with cardiac involvement. Novel therapeutic approaches are now ongoing for these diseases, also based on splicing modulation. In this review we provide an overview about ncRNAs and their behavior in muscular dystrophy and explore their links with diagnosis, prognosis and treatments, highlighting the role of regulatory RNAs in these pathologies.
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Erriquez, D.; Perini, G.; Ferlini, A. Non-Coding RNAs in Muscle Dystrophies. Int. J. Mol. Sci. 2013, 14, 19681-19704.
Erriquez D, Perini G, Ferlini A. Non-Coding RNAs in Muscle Dystrophies. International Journal of Molecular Sciences. 2013; 14(10):19681-19704.Chicago/Turabian Style
Erriquez, Daniela; Perini, Giovanni; Ferlini, Alessandra. 2013. "Non-Coding RNAs in Muscle Dystrophies." Int. J. Mol. Sci. 14, no. 10: 19681-19704.