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Int. J. Mol. Sci. 2013, 14(11), 23086-23102; doi:10.3390/ijms141123086
Review

Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

1,2,†
,
3,†
,
1
,
1
,
1
 and
1,*
1 Institute of Clinical Pharmacology, Central South University, Changsha 410078, China 2 Department of Pharmacy, Changsha Medical University, Changsha 410219, China 3 College of Medicine, Hunan Normal University, Changsha 410006, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 September 2013 / Revised: 30 October 2013 / Accepted: 4 November 2013 / Published: 21 November 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
Keywords: let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bao, M.-H.; Feng, X.; Zhang, Y.-W.; Lou, X.-Y.; Cheng, Y.; Zhou, H.-H. Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells. Int. J. Mol. Sci. 2013, 14, 23086-23102.

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