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Int. J. Mol. Sci. 2013, 14(2), 3705-3717; doi:10.3390/ijms14023705

Covalent Coupling of Nanoparticles with Low-Density Functional Ligands to Surfaces via Click Chemistry

1
NanoElectronics (NE) Group, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
2
Molecular NanoFabrication Group, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
*
Authors to whom correspondence should be addressed.
Received: 25 January 2013 / Revised: 2 February 2013 / Accepted: 5 February 2013 / Published: 7 February 2013
(This article belongs to the Special Issue Synthesis, Characterization and Application of Supramolecular Systems)
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Abstract

We demonstrate the application of the 1,3-dipolar cycloaddition (“click” reaction) to couple gold nanoparticles (Au NPs) functionalized with low densities of functional ligands. The ligand coverage on the citrate-stabilized Au NPs was adjusted by the ligand:Au surface atom ratio, while maintaining the colloidal stability of the Au NPs in aqueous solution. A procedure was developed to determine the driving forces governing the selectivity and reactivity of citrate-stabilized and ligand-functionalized Au NPs on patterned self-assembled monolayers. We observed selective and remarkably stable chemical bonding of the Au NPs to the complimentarily functionalized substrate areas, even when estimating that only 1–2 chemical bonds are formed between the particles and the substrate. View Full-Text
Keywords: gold nanoparticles; ligand coverage; click chemistry; microcontact printing; monolayers gold nanoparticles; ligand coverage; click chemistry; microcontact printing; monolayers
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Rianasari, I.; de Jong, M.P.; Huskens, J.; van der Wiel, W.G. Covalent Coupling of Nanoparticles with Low-Density Functional Ligands to Surfaces via Click Chemistry. Int. J. Mol. Sci. 2013, 14, 3705-3717.

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