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Int. J. Mol. Sci. 2013, 14(3), 4655-4669; doi:10.3390/ijms14034655

Long Non-Coding RNA in Cancer

Department of Molecular Genetics, Institute of Pathology, University of Ljubljana, SI-1000 Ljubljana, Slovenia
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 1 November 2012 / Revised: 3 January 2013 / Accepted: 31 January 2013 / Published: 26 February 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs 2013)
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Abstract

Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.
Keywords: long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA long non-coding RNA; cancer; oncogenic lncRNA; tumor suppressor lncRNA
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hauptman, N.; Glavač, D. Long Non-Coding RNA in Cancer. Int. J. Mol. Sci. 2013, 14, 4655-4669.

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