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Int. J. Mol. Sci. 2013, 14(4), 6790-6804; doi:10.3390/ijms14046790

Synthesis of 1-isopropyl-3-acyl-5-methyl-benzimidazolone Derivatives and Their Antimicrobial Activity

College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China
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Received: 22 January 2013 / Revised: 6 March 2013 / Accepted: 8 March 2013 / Published: 26 March 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [336 KB, 19 June 2014; original version 19 June 2014]   |  

Abstract

A series of N-acylated analogues of 1-isopropyl-3-acyl-5-methyl-benzimidazolone were synthesized. Bioassay results indicated that analogues 5-07 and 5-19 exhibited the most potency against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Analogues 5-02, 5-07, 5-12, 5-15, 5-19, 5-20 and 5-25 could effectively inhibit the spore germination of Botrytis cinerea. The relationship between structure and their antimicrobial activity (SAR) has also been discussed according to aliphatic acids and aromatic acids derivatives, respectively. This implied that the N-acylated derivatives of 5-methyl-benzimidazolone might be potential antimicrobial agents. View Full-Text
Keywords: 5-methyl-benzimidazolone; N-acylated derivatives; antimicrobial activity 5-methyl-benzimidazolone; N-acylated derivatives; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xu, N.; Yang, C.; Gan, X.; Wei, S.; Ji, Z. Synthesis of 1-isopropyl-3-acyl-5-methyl-benzimidazolone Derivatives and Their Antimicrobial Activity. Int. J. Mol. Sci. 2013, 14, 6790-6804.

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