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Int. J. Mol. Sci. 2013, 14(5), 9319-9337; doi:10.3390/ijms14059319

Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
School of Public Health, Shandong University, Jinan 250100, China
Author to whom correspondence should be addressed.
Received: 28 February 2013 / Revised: 17 April 2013 / Accepted: 18 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2013)
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The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein. View Full-Text
Keywords: nanotoxicity; reproductivity; development; animal model; zebrafish nanotoxicity; reproductivity; development; animal model; zebrafish

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sun, J.; Zhang, Q.; Wang, Z.; Yan, B. Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models. Int. J. Mol. Sci. 2013, 14, 9319-9337.

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