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Int. J. Mol. Sci. 2013, 14(5), 9487-9496; doi:10.3390/ijms14059487

The Role of microRNA in Gastric Malignancy

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan
Author to whom correspondence should be addressed.
Received: 27 March 2013 / Revised: 19 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs 2013)
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Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized.
Keywords: microRNA; Helicobacter pylori; gastric cancer microRNA; Helicobacter pylori; gastric cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nishizawa, T.; Suzuki, H. The Role of microRNA in Gastric Malignancy. Int. J. Mol. Sci. 2013, 14, 9487-9496.

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