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/Title (HDAC6 and Ovarian Cancer)
/Author (Joshua Haakenson and Xiaohong Zhang)
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/Subject (The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular processes related to cancer, including oncogenesis, the cell stress response, motility, and myriad signaling pathways. Many of the lessons learned from other cancers can be applied to ovarian cancer as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin, tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm to carry out these cancerous functions. Not all pro-cancer interactions of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for cancer treatment continues to expand in recent years, and more potent and specific HDAC6 inhibitors are required to effectively down-regulate the tumor-prone cell signaling pathways responsible for ovarian cancer. )
/Keywords (HDAC6; ovarian cancer; cancer-related signaling pathways; HDAC6 inhibitors; cell stress response; motility; oncogenesis; histone deacetylase)
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2013-05-13T13:55:18+08:00
PScript5.dll Version 5.2.2
2013-05-13T13:56:16+08:00
Acrobat Distiller 10.0.0 (Windows)
HDAC6; ovarian cancer; cancer-related signaling pathways; HDAC6 inhibitors; cell stress response; motility; oncogenesis; histone deacetylase
application/pdf
HDAC6 and Ovarian Cancer
Joshua Haakenson and Xiaohong Zhang
The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular processes related to cancer, including oncogenesis, the cell stress response, motility, and myriad signaling pathways. Many of the lessons learned from other cancers can be applied to ovarian cancer as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin, tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm to carry out these cancerous functions. Not all pro-cancer interactions of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for cancer treatment continues to expand in recent years, and more potent and specific HDAC6 inhibitors are required to effectively down-regulate the tumor-prone cell signaling pathways responsible for ovarian cancer.
HDAC6
ovarian cancer
cancer-related signaling pathways
HDAC6 inhibitors
cell stress response
motility
oncogenesis
histone deacetylase
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