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Int. J. Mol. Sci. 2013, 14(5), 9790-9802; doi:10.3390/ijms14059790

D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways

1
School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
2
Department of Urology, Buddhist Tzu Chi General Hospital Taichung Branch, Taichung 427, Taiwan
3
Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan
4
Department of Pharmacology, School of Medicine, China Medical University, Taichung 404, Taiwan
5
Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan
6
Department of Urology, China Medical University Hospital, Taichung 404, Taiwan
7
Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 29 March 2013 / Revised: 26 April 2013 / Accepted: 2 May 2013 / Published: 8 May 2013
(This article belongs to the Special Issue Molecular Research in Urology)
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Abstract

Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. D-pinitol, a 3-methoxy analogue of d-chiro-inositol, was identified as an active principle in soy foods and legumes, and it has been proven to induce tumor apoptosis and metastasis of cancer cells. In this study, we investigated the anti-metastasis effects of D-pinitol in human prostate cancer cells. We found that D-pinitol reduced the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells. Treatment of prostate cancer cells with D-pinitol reduced mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerted its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-kB activation. Thus, D-pinitol may be a novel anti-metastasis agent for the treatment of prostate cancer metastasis. View Full-Text
Keywords: D-pinitol; integrin; prostate cancer; migration; FAK D-pinitol; integrin; prostate cancer; migration; FAK
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lin, T.-H.; Tan, T.-W.; Tsai, T.-H.; Chen, C.-C.; Hsieh, T.-F.; Lee, S.-S.; Liu, H.-H.; Chen, W.-C.; Tang, C.-H. D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways. Int. J. Mol. Sci. 2013, 14, 9790-9802.

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