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Int. J. Mol. Sci. 2013, 14(5), 9883-9892; doi:10.3390/ijms14059883

Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment

*  and
Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
* Author to whom correspondence should be addressed.
Received: 13 April 2013 / Revised: 19 April 2013 / Accepted: 3 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy.
Keywords: Rab GTPase; exosome; cancer; extracellular vesicle Rab GTPase; exosome; cancer; extracellular vesicle
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hendrix, A.; De Wever, O. Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment. Int. J. Mol. Sci. 2013, 14, 9883-9892.

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