Increased Susceptibility of Radiation-Induced Intestinal Apoptosis in SMP30 KO Mice
Abstract
:1. Introduction
2. Results
2.1. Distribution of Apoptosis
2.2. Expression of BAX
2.3. Expression of Bcl-2
2.4. The Ratio of BAX/Bcl-2
3. Discussion
4. Experimental Section
4.1. Animal Models and Experimental Design
4.2. Irradiation
4.3. Histology and Assessing Apoptosis
4.4. Immunohistochemistry
4.5. Statistical Analysis
5. Conclusions
Acknowledgments
Conflict of Interest
References
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Group | Treatment | SMP30-WT | SMP30-KO |
---|---|---|---|
N | Vit.C-free diet + tap water | 6 | 5 |
VC | Vit.C-free diet + Vit.C 2.5mg/ml in drinking water | 6 | 5 |
IR-1 Gy | Vit.C-free diet + tap water + IR-1 Gy | 7 | 6 |
IR-3 Gy | Vit.C-free diet + tap water + IR-3 Gy | 7 | 6 |
IR-5 Gy | Vit.C-free diet + tap water + IR-5 Gy | 7 | 6 |
IR-9 Gy | Vit.C-free diet + tap water + IR-9 Gy | 7 |
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Goo, M.-J.; Park, J.-K.; Hong, I.-H.; Kim, A.-Y.; Lee, E.-M.; Lee, E.-J.; Hwang, M.; Jeong, K.-S. Increased Susceptibility of Radiation-Induced Intestinal Apoptosis in SMP30 KO Mice. Int. J. Mol. Sci. 2013, 14, 11084-11095. https://doi.org/10.3390/ijms140611084
Goo M-J, Park J-K, Hong I-H, Kim A-Y, Lee E-M, Lee E-J, Hwang M, Jeong K-S. Increased Susceptibility of Radiation-Induced Intestinal Apoptosis in SMP30 KO Mice. International Journal of Molecular Sciences. 2013; 14(6):11084-11095. https://doi.org/10.3390/ijms140611084
Chicago/Turabian StyleGoo, Moon-Jung, Jin-Kyu Park, Il-Hwa Hong, Ah-Young Kim, Eun-Mi Lee, Eun-Joo Lee, Meeyul Hwang, and Kyu-Shik Jeong. 2013. "Increased Susceptibility of Radiation-Induced Intestinal Apoptosis in SMP30 KO Mice" International Journal of Molecular Sciences 14, no. 6: 11084-11095. https://doi.org/10.3390/ijms140611084