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Int. J. Mol. Sci. 2013, 14(6), 11861-11870; doi:10.3390/ijms140611861

Prevention of Intra-Abdominal Adhesion by Bi-Layer Electrospun Membrane

Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai 200233, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 26 April 2013 / Revised: 27 May 2013 / Accepted: 29 May 2013 / Published: 4 June 2013
(This article belongs to the Section Material Sciences and Nanotechnology)
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The aim of this study was to compare the anti-adhesion efficacy of a bi-layer electrospun fibrous membrane consisting of hyaluronic acid-loaded poly(ε-caprolactone) (PCL) fibrous membrane as the inner layer and PCL fibrous membrane as the outer layer with a single-layer PCL electrospun fibrous membrane in a rat cecum abrasion model. The rat model utilized a cecal abrasion and abdominal wall insult surgical protocol. The bi-layer and PCL membranes were applied between the cecum and the abdominal wall, respectively. Control animals did not receive any treatment. After postoperative day 14, a visual semiquantitative grading scale was used to grade the extent of adhesion. Histological analysis was performed to reveal the features of adhesion tissues. Bi-layer membrane treated animals showed significantly lower adhesion scores than control animals (p < 0.05) and a lower adhesion score compared with the PCL membrane. Histological analysis of the bi-layer membrane treated rat rarely demonstrated tissue adhesion while that of the PCL membrane treated rat and control rat showed loose and dense adhesion tissues, respectively. Bi-layer membrane can efficiently prevent adhesion formation in abdominal cavity and showed a significantly decreased adhesion tissue formation compared with the control.
Keywords: postoperative adhesion; hyaluronic acid; electrospun; barrier; adhesion prevention postoperative adhesion; hyaluronic acid; electrospun; barrier; adhesion prevention
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jiang, S.; Wang, W.; Yan, H.; Fan, C. Prevention of Intra-Abdominal Adhesion by Bi-Layer Electrospun Membrane. Int. J. Mol. Sci. 2013, 14, 11861-11870.

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