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Int. J. Mol. Sci. 2013, 14(7), 13063-13077; doi:10.3390/ijms140713063

New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium

1,* , 2
1 Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan 2 Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 4 Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan 5 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 6 Taitung District Agricultural Research and Extension Station, Taitung 950, Taiwan
* Author to whom correspondence should be addressed.
Received: 16 April 2013 / Revised: 3 June 2013 / Accepted: 8 June 2013 / Published: 25 June 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (517). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 36, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
Keywords: Hedychium coronarium; Zingiberaceae; labdane-type diterpenoid; anti-inflammatory activity Hedychium coronarium; Zingiberaceae; labdane-type diterpenoid; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, J.-J.; Ting, C.-W.; Wu, Y.-C.; Hwang, T.-L.; Cheng, M.-J.; Sung, P.-J.; Wang, T.-C.; Chen, J.-F. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. Int. J. Mol. Sci. 2013, 14, 13063-13077.

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