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Int. J. Mol. Sci. 2013, 14(8), 16365-16385; doi:10.3390/ijms140816365

Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention

1
Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy
2
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy
*
Author to whom correspondence should be addressed.
Received: 22 July 2013 / Revised: 25 July 2013 / Accepted: 26 July 2013 / Published: 7 August 2013
(This article belongs to the Special Issue Pathogenesis and Prevention of Colorectal Cancer)
View Full-Text   |   Download PDF [236 KB, uploaded 19 June 2014]

Abstract

Research conducted during the past 30 years has increased our understanding of the mechanisms involved in colorectal cancer initiation and development. The findings have demonstrated the existence of at least three pathways: chromosomal instability, microsatellite instability and CpG island methylator phenotype. Importantly, new studies have shown that inflammation and microRNAs contribute to colorectal carcinogenesis. Recent data have demonstrated that several genetic and epigenetic changes are important in determining patient prognosis and survival. Furthermore, some of these mechanisms are related to patients’ response to drugs, such as aspirin, which could be used for both chemoprevention and treatment in specific settings. Thus, in the near future, we could be able to predict disease behavior based on molecular markers found on tumors, and direct the best treatment options for patients. View Full-Text
Keywords: colorectal cancer; chromosomal instability; microsatellite instability; DNA methylation; aspirin colorectal cancer; chromosomal instability; microsatellite instability; DNA methylation; aspirin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Colussi, D.; Brandi, G.; Bazzoli, F.; Ricciardiello, L. Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention. Int. J. Mol. Sci. 2013, 14, 16365-16385.

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