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Correction published on 16 May 2016, see Int. J. Mol. Sci. 2016, 17(5), 734.

Int. J. Mol. Sci. 2014, 15(6), 10926-10935; doi:10.3390/ijms150610926
Article

The Constituents of Michelia compressa var. formosana and Their Bioactivities

1,* , 2
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4
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 and
4,*
1 Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan 2 Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan 3 Department of Pharmacy, China Medical University, Taichung 40402, Taiwan 4 Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan 5 Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan 6 School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan
* Authors to whom correspondence should be addressed.
Received: 2 April 2014 / Revised: 8 May 2014 / Accepted: 19 May 2014 / Published: 17 June 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM.
Keywords: Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chan, Y.-Y.; Juang, S.-H.; Huang, G.-J.; Liao, Y.-R.; Chen, Y.-F.; Wu, C.-C.; Chang, H.-T.; Wu, T.-S. The Constituents of Michelia compressa var. formosana and Their Bioactivities. Int. J. Mol. Sci. 2014, 15, 10926-10935.

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