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Int. J. Mol. Sci. 2014, 15(6), 9826-9843; doi:10.3390/ijms15069826
Article

Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

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1 Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China 2 National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University Clinical School of Medicine, Nanjing 210002, China 3 School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China 4 Department of Infectious Diseases, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China 5 Institute of Disease Control and Prevention, Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, China 6 Department of Clinical Laboratory, Nanjing Second Hospital, Nanjing 210003, China 7 Department of Pharmacology, Nantong University Medical College, Nantong 226019, China 8 School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 March 2014 / Revised: 19 May 2014 / Accepted: 21 May 2014 / Published: 3 June 2014
(This article belongs to the Special Issue Molecular Bases of Cancer Research)
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Abstract

Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide polymorphisms (SNPs) in a region including HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277534) and genotyped SNPs in 702 cases and 342 healthy controls from the Chinese population using TaqMan SNP genotyping assay. Moreover, the exon 2 of the HLA-DPA1 and HLA-DPB1 genes were amplified and determined by sequencing-based typing (SBT). The results showed that rs3077 significantly increased the risk of chronic HCV infection in additive models and dominant models (odds ratio (OR) = 1.32 and 1.53). The rs3077 also contributed to decrease the risk of anti-F antibody generation in additive models and dominant models (OR = 0.46 and 0.56). Subsequent analyses revealed the risk haplotypes (DPA1*0103-DPB1*0501 and DPA1*0103-DPB1*0201) and protective haplotypes (DPA1*0202-DPB1*0501 and DPA1*0202-DPB1*0202) to chronic HCV infection. Moreover, we also found that the haplotype of DPA1*0103-DPB1*0201 and DPA1*0202-DPB1*0202 were associated with the anti-F antibody generation. Our findings show that genetic variants in HLA-DP gene are associated with chronic HCV infection and anti-F antibody generation.
Keywords: F protein; hepatitis C virus; human leukocyte antigen-DP; polymorphism F protein; hepatitis C virus; human leukocyte antigen-DP; polymorphism
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xu, X.; Yue, M.; Jiang, L.; Deng, X.; Zhang, Y.; Zhang, Y.; Zhu, D.; Xiao, W.; Zhou, Z.; Yao, W.; Kong, J.; Yu, X.; Wei, J. Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population. Int. J. Mol. Sci. 2014, 15, 9826-9843.

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