Table of Contents
Int. J. Mol. Sci., Volume 17, Issue 11 (November 2016)
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Cover Story Fireworks of p53 Proteoforms Illustrate the Protein Structure–Function Continuum Concept p53 is a [...] Read more. Fireworks of p53 Proteoforms Illustrate the Protein Structure–Function Continuum Concept p53 is a multifunctional protein with high intrinsic disorder content. It homotetramerizes, interacts with myriads of binding partners, contains numerous posttranslational modifications, has several isoforms, and is commonly mutated in cancers. Therefore, p53 serves as an illustration of the protein structure–function continuum concept, where generation of multiple proteoforms by various means define the ability of a protein to have a multitude of structurally and functionally different states. View this paper.