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Int. J. Mol. Sci. 2017, 18(1), 134; doi:10.3390/ijms18010134

Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3

1,†
,
2,†
,
1,†
,
1
,
1
,
2
,
1,* and 1,*
1
Department of Thoracic Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2
Department of Oncology, Cancer Center, People’s Liberation Army General Hospital of Shenyang Military Region, Shenyang 110016, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Marco G. Patti
Received: 4 November 2016 / Revised: 21 December 2016 / Accepted: 4 January 2017 / Published: 12 January 2017
(This article belongs to the Special Issue Gastroesophageal Reflux Disease: It Is More than Just Heartburn)
View Full-Text   |   Download PDF [3350 KB, uploaded 12 January 2017]   |  

Abstract

Shp2 (Src-homology 2 domain-containing phosphatase 2) was originally reported as an oncogene in kinds of solid tumors and hematologic malignancies. However, recent studies indicated that Shp2 may act as tumor suppressors in several tumor types. We investigated the function of Shp2 in esophageal squamous cell cancer (ESCC). The expression level of Shp2 was analyzed in tumor tissues in comparison with adjacent normal tissues of ESCC patients by immunohistochemistry and Western blot. Shp2 was knocked down by Short hairpin RNA to evaluate its function in ESCC cell lines. The relationship between Shp2 and p-Stat3 (signal transducer and activator of transcription 3) in human ESCC tissues was statistically examined. A significant low expression of Shp2 was found in ESCC tissues. Low expression of Shp2 was related to poorer overall survival in patients from The Cancer Genome Atlas (TCGA) dataset. Knockdown of Shp2 increased the growth of ESCC cell lines both in vivo and vitro. Activation of Stat3 (p-Stat3) was induced by Shp2 depletion. Expression of p-Stat3 was negatively correlated with Shp2 expression in ESCC tissues. Furthermore, knockdown of Shp2 attenuated cisplatin-sensitivity of ESCC cells. Shp2 might suppress the proliferation of ESCC by dephosphorylation of p-Stat3 and represents a novel research field for targeted therapy. View Full-Text
Keywords: esophageal squamous cell cancer; proliferation; Shp2 esophageal squamous cell cancer; proliferation; Shp2
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MDPI and ACS Style

Qi, C.; Han, T.; Tang, H.; Huang, K.; Min, J.; Li, J.; Ding, X.; Xu, Z. Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3. Int. J. Mol. Sci. 2017, 18, 134.

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