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Int. J. Mol. Sci. 2017, 18(11), 2412; doi:10.3390/ijms18112412

Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents

1
Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98000, Mexico
2
Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
3
Department of Pathology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
4
Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
These authors share the first authorship of this paper.
*
Author to whom correspondence should be addressed.
Received: 16 October 2017 / Revised: 31 October 2017 / Accepted: 11 November 2017 / Published: 14 November 2017
(This article belongs to the Special Issue Bioactive Phenolics and Polyphenols 2018)
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Abstract

Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction. Crataegus oxyacantha (Co) and Rosmarinus officinalis (Ro) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from Co and Ro on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c) Ro extract-treated myocardial infarction (MI-Ro); (d) Co extract-treated myocardial infarction (MI-Co); or (e) Ro+Co-treated myocardial infarction (MI-Ro+Co). Ro and Co treatments increased total antioxidant capacity, the expression of superoxide dismutase (SOD)-Cu2+/Zn2+, SOD-Mn2+, and catalase, with the subsequent decline of malondialdehyde and 8-hydroxy-2′-deoxyguanosine levels. The extracts diminished vasoconstrictor peptide levels (angiotensin II and endothelin-1), increased vasodilators agents (angiotensin 1–7 and bradikinin) and improved nitric oxide metabolism. Polyphenol treatment restored the left intraventricular pressure and cardiac mechanical work. We conclude that Ro and Co treatment attenuate morphological and functional ischemic-related changes by both an oxidant load reduction and improvement of the balance between vasoconstrictors and vasodilators. View Full-Text
Keywords: Crataegus oxyacantha; Rosmarinus officinalis; myocardial function; antioxidant status; vasoconstrictor; vasodilators Crataegus oxyacantha; Rosmarinus officinalis; myocardial function; antioxidant status; vasoconstrictor; vasodilators
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MDPI and ACS Style

Cuevas-Durán, R.E.; Medrano-Rodríguez, J.C.; Sánchez-Aguilar, M.; Soria-Castro, E.; Rubio-Ruíz, M.E.; Del Valle-Mondragón, L.; Sánchez-Mendoza, A.; Torres-Narvaéz, J.C.; Pastelín-Hernández, G.; Ibarra-Lara, L. Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents. Int. J. Mol. Sci. 2017, 18, 2412.

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