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Int. J. Mol. Sci. 2017, 18(4), 875; doi:10.3390/ijms18040875

Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms

1
Department of Periodontology, University of Florida, Gainesville, FL 32610, USA
2
Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
3
Departments of Surgery, University of Florida, Gainesville, FL 32610, USA
4
Michael E. Debakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
5
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Christophe Nicot
Received: 16 March 2017 / Revised: 10 April 2017 / Accepted: 11 April 2017 / Published: 20 April 2017
(This article belongs to the Section Molecular Diagnostics)
View Full-Text   |   Download PDF [2570 KB, uploaded 20 April 2017]   |  

Abstract

Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA and AAA operative specimens compared to controls. We observed significant upregulation of miR-221 and downregulation of miR-1 and -133 in TAA specimens. In contrast, upregulation of miR-146a and downregulation of miR-145 and -331-3p were found only for AAA specimens. Upregulation of miR-126 and -486-5p and downregulation of miR-30c-2*, -155, and -204 were observed in specimens of TAAs and AAAs. The data reveal microRNA expression signatures unique to aneurysm location and common to both thoracic and abdominal pathologies. Thus, changes in miR-1, -29a, -133a, and -221 are involved in TAAs and miR-145, -146, and -331-3p impact AAAs. This work validates prior studies on microRNA expression in aneurysmal diseases. View Full-Text
Keywords: thoracic aortic aneurysm; abdominal aortic aneurysm; microRNA thoracic aortic aneurysm; abdominal aortic aneurysm; microRNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Venkatesh, P.; Phillippi, J.; Chukkapalli, S.; Rivera-Kweh, M.; Velsko, I.; Gleason, T.; VanRyzin, P.; Aalaei-Andabili, S.H.; Ghanta, R.K.; Beaver, T.; Chan, E.K.L.; Kesavalu, L. Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. Int. J. Mol. Sci. 2017, 18, 875.

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