Int. J. Mol. Sci. 2017, 18(4), 877; doi:10.3390/ijms18040877
Regulation of Ubiquitin Enzymes in the TGF-β Pathway
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
Academic Editor: Nobuhiro Nakamura
Received: 24 March 2017 / Revised: 15 April 2017 / Accepted: 18 April 2017 / Published: 20 April 2017
(This article belongs to the Special Issue Ubiquitin System)
Abstract
The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberrations in these enzymes are frequently observed to dysregulate the pathway causing diseases such as bone disorders, cancer and metastasis. These enzymes and their counterparts are increasingly being tested as druggable targets, and thus a deeper understanding of the enzymes is required. This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-β pathway and how they are regulated. View Full-TextKeywords:
transforming growth factor-β (TGF-β); ubiquitin; deubiquitylating enzymes (DUBs); SMAD ubiquitination regulatory factor (SMURF); ubiquitin–proteasome system (UPS)
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Iyengar, P.V. Regulation of Ubiquitin Enzymes in the TGF-β Pathway. Int. J. Mol. Sci. 2017, 18, 877.
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