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Int. J. Mol. Sci. 2017, 18(4), 877; doi:10.3390/ijms18040877

Regulation of Ubiquitin Enzymes in the TGF-β Pathway

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
Academic Editor: Nobuhiro Nakamura
Received: 24 March 2017 / Revised: 15 April 2017 / Accepted: 18 April 2017 / Published: 20 April 2017
(This article belongs to the Special Issue Ubiquitin System)
View Full-Text   |   Download PDF [873 KB, uploaded 20 April 2017]   |  


The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberrations in these enzymes are frequently observed to dysregulate the pathway causing diseases such as bone disorders, cancer and metastasis. These enzymes and their counterparts are increasingly being tested as druggable targets, and thus a deeper understanding of the enzymes is required. This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-β pathway and how they are regulated. View Full-Text
Keywords: transforming growth factor-β (TGF-β); ubiquitin; deubiquitylating enzymes (DUBs); SMAD ubiquitination regulatory factor (SMURF); ubiquitin–proteasome system (UPS) transforming growth factor-β (TGF-β); ubiquitin; deubiquitylating enzymes (DUBs); SMAD ubiquitination regulatory factor (SMURF); ubiquitin–proteasome system (UPS)

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Iyengar, P.V. Regulation of Ubiquitin Enzymes in the TGF-β Pathway. Int. J. Mol. Sci. 2017, 18, 877.

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