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Int. J. Mol. Sci. 2017, 18(9), 1962; doi:10.3390/ijms18091962

Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats

1
Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan
2
Translational Research Center, Ehime University Hospital, Shitsukawa, Toon 791-0295, Ehime, Japan
3
Division of Bio-imaging, Proteo-Science Center, Ehime University, Shitsukawa, Toon 791-0295, Ehime, Japan
4
Ozu Municipal Hospital, Nishiozu, Ozu 795-8501, Ehime, Japan
*
Author to whom correspondence should be addressed.
Received: 26 July 2017 / Revised: 29 August 2017 / Accepted: 4 September 2017 / Published: 13 September 2017
(This article belongs to the Special Issue Neuroprotective Strategies 2017)
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Abstract

Despite the availability of several modalities of treatment, including surgery, pharmacological agents, and nerve blocks, neuropathic pain is often unresponsive and sometimes progresses to intractable chronic pain. Although exercise therapy is a candidate for treatment of neuropathic pain, the mechanism underlying its efficacy has not been elucidated. To clarify the molecular mechanism for pain relief induced by exercise, we measured Rnf34 and Pacap mRNA levels in the spinal cord dorsal horn of SNL rats, a model of neuropathic pain. SNL model rats exhibited stable mechanical hyperalgesia for at least 6 weeks. When the rats were forced to exercise on a treadmill, mechanical and thermal hyperalgesia were significantly ameliorated compared with the non-exercise group. Accordingly, gene expression level of Rnf34 and Pacap were also significantly altered in the time course analysis after surgery. These results suggest that exercise therapy possibly involves pain relief in SNL rats by suppressing Rnf34 and Pacap expression in the spinal cord. View Full-Text
Keywords: neuropathic pain; exercise therapy; SNL model; LMD; RNA sequence; RNF34; PACAP neuropathic pain; exercise therapy; SNL model; LMD; RNA sequence; RNF34; PACAP
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MDPI and ACS Style

Yamaoka, S.; Oshima, Y.; Horiuchi, H.; Morino, T.; Hino, M.; Miura, H.; Ogata, T. Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats. Int. J. Mol. Sci. 2017, 18, 1962.

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