New Insights into the Tumor Microenvironment Utilizing Protein Array Technology
AbstractThe tumor microenvironment (TME) is a considerably heterogeneous niche, which is created by tumor cells, the surrounding tumor stroma, blood vessels, infiltrating immune cells, and a variety of associated stromal cells. Intercellular communication within this niche is driven by soluble proteins synthesized by local tumor and stromal cells and include chemokines, growth factors, interferons, interleukins, and angiogenic factors. The interaction of tumor cells with their microenvironment is essential for tumorigenesis, tumor progression, growth, and metastasis, and resistance to drug therapy. Protein arrays enable the parallel detection of hundreds of proteins in a small amount of biological sample. Recent data have demonstrated that the application of protein arrays may yield valuable information regarding the structure and functional mechanisms of the TME. In this review, we will discuss protein array technologies and their applications in TME analysis to discern pathways involved in promoting the tumorigenic phenotype. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Huang, W.; Luo, S.; Burgess, R.; Yi, Y.-H.; Huang, G.F.; Huang, R.-P. New Insights into the Tumor Microenvironment Utilizing Protein Array Technology. Int. J. Mol. Sci. 2018, 19, 559.
Huang W, Luo S, Burgess R, Yi Y-H, Huang GF, Huang R-P. New Insights into the Tumor Microenvironment Utilizing Protein Array Technology. International Journal of Molecular Sciences. 2018; 19(2):559.Chicago/Turabian Style
Huang, Wei; Luo, Shuhong; Burgess, Rob; Yi, Yu-Hua; Huang, Gordon F.; Huang, Ruo-Pan. 2018. "New Insights into the Tumor Microenvironment Utilizing Protein Array Technology." Int. J. Mol. Sci. 19, no. 2: 559.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.