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Int. J. Mol. Sci. 2018, 19(6), 1796; https://doi.org/10.3390/ijms19061796

Bioengineering Approaches for Bladder Regeneration

1
Faculty of Veterinary and Experimental Sciences, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
2
Department of Urology, La Fe University and Polytechnic Hospital and Health Research Institute, Hospital La Fe, 46026 Valencia, Spain
3
Neuronal Regeneration Lab, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Received: 26 April 2018 / Revised: 6 June 2018 / Accepted: 10 June 2018 / Published: 17 June 2018
(This article belongs to the Special Issue Cell Colonization in Scaffolds)
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Abstract

Current clinical strategies for bladder reconstruction or substitution are associated to serious problems. Therefore, new alternative approaches are becoming more and more necessary. The purpose of this work is to review the state of the art of the current bioengineering advances and obstacles reported in bladder regeneration. Tissue bladder engineering requires an ideal engineered bladder scaffold composed of a biocompatible material suitable to sustain the mechanical forces necessary for bladder filling and emptying. In addition, an engineered bladder needs to reconstruct a compliant muscular wall and a highly specialized urothelium, well-orchestrated under control of autonomic and sensory innervations. Bioreactors play a very important role allowing cell growth and specialization into a tissue-engineered vascular construct within a physiological environment. Bioprinting technology is rapidly progressing, achieving the generation of custom-made structural supports using an increasing number of different polymers as ink with a high capacity of reproducibility. Although many promising results have been achieved, few of them have been tested with clinical success. This lack of satisfactory applications is a good reason to discourage researchers in this field and explains, somehow, the limited high-impact scientific production in this area during the last decade, emphasizing that still much more progress is required before bioengineered bladders become a commonplace in the clinical setting. View Full-Text
Keywords: bladder regeneration; bioreactors; c; regenerative medicine; stem cells; scaffolds bladder regeneration; bioreactors; c; regenerative medicine; stem cells; scaffolds
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Serrano-Aroca, Á.; Vera-Donoso, C.D.; Moreno-Manzano, V. Bioengineering Approaches for Bladder Regeneration. Int. J. Mol. Sci. 2018, 19, 1796.

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