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Int. J. Mol. Sci., Volume 7, Issue 4 (April 2006), Pages 111-129

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Research

Open AccessArticle Studies on the Interaction between Zinc-Hydroxybenzoite Complex and Genomic DNA
Int. J. Mol. Sci. 2006, 7(4), 111-118; doi:10.3390/i7040111
Received: 14 November 2005 / Revised: 2 March 2006 / Accepted: 20 March 2006 / Published: 7 April 2006
Cited by 10 | PDF Full-text (74 KB) | HTML Full-text | XML Full-text
Abstract
Zinc-Hydroxybenzoite ([Zn (H20)6] (p-HO-C6H4COO)22H20) complex which wassynthesized and characterized by instrumental methods and the DNA samples which hadbeen isolated from cattle were allowed to interact at 37 oC for different
[...] Read more.
Zinc-Hydroxybenzoite ([Zn (H20)6] (p-HO-C6H4COO)22H20) complex which wassynthesized and characterized by instrumental methods and the DNA samples which hadbeen isolated from cattle were allowed to interact at 37 oC for different time periods. Theinteraction of genomic DNA with this complex has been followed by agarose gelelectrophoresis at 50 V for 2 h. When DNA samples were allowed to interact with this metalcomplex, it was found that band intensities changed with the concentrations of the complex.In the result of interaction between this complex and genomic DNA samples, it wasdetermined that the intensities of bands were changed at the different concentrations of thecomplex. The brightness of the bands was increased and mobility of the bands wasdecreased, indicating the occurrence of increased covalent binding of the metal complexwith DNA. In this study it was concluded that the damage effect of ascorbate was reducedby Zinc-Hydroxybenzoite. Full article
Open AccessArticle QSAR of Some N1-Aryl/Heteroarylaminomethyl/ethyl-1,2,4-Triazoles Part II: Antimicrobial Activity Against BacillusSubtilis
Int. J. Mol. Sci. 2006, 7(4), 119-129; doi:10.3390/i7040119
Received: 27 December 2005 / Revised: 15 August 2006 / Accepted: 20 April 2006 / Published: 26 April 2006
Cited by 6 | PDF Full-text (80 KB) | HTML Full-text | XML Full-text
Abstract
QSAR analysis of a series of previously synthesized N1-aryl-amino/methyl/ethyl-1,2,4-triazole and N1-heteroarylamino/methyl/ethyl-1,2,4-triazolederivatives tested for growth inhibitory activity against Bacillus subtilis, was performedusing the computer-assisted multiple regression procedure. Using the Hansch and FreeWilson approaches the activity contribution for either the aminomethyl/aminoethyl
[...] Read more.
QSAR analysis of a series of previously synthesized N1-aryl-amino/methyl/ethyl-1,2,4-triazole and N1-heteroarylamino/methyl/ethyl-1,2,4-triazolederivatives tested for growth inhibitory activity against Bacillus subtilis, was performedusing the computer-assisted multiple regression procedure. Using the Hansch and FreeWilson approaches the activity contribution for either the aminomethyl/aminoethyl unitor the aromatic/heteroaromatic ring was determined from the correlation equation. Full article

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