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1-Hydroxymethyl-3-phenyl-5-methylpyrazole
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Volume 2005
Issue 3
10.3390/M426
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Short Note

1-Hydroxymethyl-3,5-diphenylpyrazole

by
Ibrahim Bouabdallah
,
Abdelkrim Ramdani
* and
Rachid Touzani
Laboratory of Physical Organic Chemistry, Department of Chemistry, Faculty of Sciences, University Mohammed the first BP 524, 60 000 Oujda, Morocco
*
Author to whom correspondence should be addressed.
Molbank 2005, 2005(3), M426; https://doi.org/10.3390/M426
Submission received: 20 May 2004 / Accepted: 9 July 2004 / Published: 1 August 2005
Versions Notes

Keywords:
pyrazol; formaldehyde

Molbank 2005 m426 i001
To a solution of 3,5-diphenylpyrazole 1 [1] (200 mg, 0.90 mmol) in ethanol (10 mL) was added formaldehyde 2 (110 mg, 1.28 mmol, 35 %) and the mixture was refluxed for two hours [2,3]. The reaction was continued at room temperature for 12 h. The mixture was concentrated at reduced pressure. The residue was purified by recrystallization to afford the product 3 as a white solid.
Yield: 160 mg, 71 %.
Melting point: 122-123°C (CH3CH2OH).
IR (KBr, cm−1): 3120 (νO-H); 1530 (νC=C); 1440, 1423, 1380, 1360, 1260 (δO-H); 1180, 1150, 1131, 1030, 1010, 927, 905, 760, 690.
1H-NMR (200 MHz, CDCl3): δ= 7.89 (m, 2 H, CH ph : o-H); 7.74 (m, 2 H, CH ph : o-H); 7.55 (m, 3 H, CH ph : m-H, p-H); 7.49 (m, 3 H, CH ph : m-H, p-H); 6.75 (s, 1H, CH pz); 5.70 (s, 2 H, CH2).
MS (EI, 70eV; m/z): 250; 220; 191; 165; 143; 126; 110; 89; 77; 63; 51; 40.

Supplementary materials

Supplementary File 1Supplementary File 2Supplementary File 3

References and Notes:

  1. Ali, S. S.; Ashraf, C. M.; Younas, M.; Ehsan, A. Pak. J. Sci. Ind. Res. 1993, 36, 12, 502-510.
  2. Driessen, W. J. R.. Neth. Chem. Soc. 1982, 101, 441.
  3. Bouabdallah, I.; Zidane, I; Ramdani, A. Rapport de DESA, Faculty of Sciences: Oujda, Maroc, 2001.
  • Sample Availability: Available from MDPI.

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MDPI and ACS Style

Bouabdallah, I.; Ramdani, A.; Touzani, R. 1-Hydroxymethyl-3,5-diphenylpyrazole. Molbank 2005, 2005, M426. https://doi.org/10.3390/M426

AMA Style

Bouabdallah I, Ramdani A, Touzani R. 1-Hydroxymethyl-3,5-diphenylpyrazole. Molbank. 2005; 2005(3):M426. https://doi.org/10.3390/M426

Chicago/Turabian Style

Bouabdallah, Ibrahim, Abdelkrim Ramdani, and Rachid Touzani. 2005. "1-Hydroxymethyl-3,5-diphenylpyrazole" Molbank 2005, no. 3: M426. https://doi.org/10.3390/M426

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