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Volume 2007
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Short Note

Synthesis of 4-Amino-1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

by
Marta Struga
* and
Jerzy Kossakowski
The Medical University, Department of Medical Chemistry, 3 Oczki Str., 02-007 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Molbank 2007, 2007(2), M534; https://doi.org/10.3390/M534
Submission received: 27 September 2006 / Accepted: 16 January 2007 / Published: 31 May 2007
Versions Notes

Various imide derivatives of 1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2) have been reported and shown to exhibit an anxiolytic activities [1].
Starting materials e.g. 1,2,3,4-tetramethyl-1,3-cyclopentadiene, and furan-2,5-dione were commercially available reagents.
Molbank 2007 m534 i001
1,7,8,9-Tetramethyl-4-oxa-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (1).
The synthesis of (1) was performed from 1,2,3,4-tetramethyl-1,3-cyclopentadiene and furan-2,5-dione according to the method described previously [2]. (Lit. m.p. 108-1090C. Yield 68 %.)
White crystals, yield 76 %.
Melting point: 110°C.
1H NMR (400 MHz, CDCl3) δ (ppm): 3.35 (s, 2H, CH-C=O); 3.29 (s, 12H, CH3); 2.72 (s, 2H, CH2).
13C-NMR (100 MHz, CDCl3) δ (ppm): 171.3, 138.4, 137.6, 63.9, 56.3, 54.4, 16.6, 11.0.
ESI MS: m/z = 243.3 [M + Na]+ (100%).
Elemental Analysis: Calculated for C13H16O3 (220.26): C, 70.89 %; H, 7.32 %. Found: C, 70.92 %; H, 7.23 %.
4-Amino-1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2).
A mixture of anhydride 1 (0.01 mole) and hydrazine hydrate (80% water solution) (10 ml) was refluxed for 5 h. The solvents were evaporated. The residue was purified by a column chromatography (silica gel, chloroform/methanol 19:1) to give compound 2.
White crystals, yield 89 %.
Melting point: 161°C.
1H NMR (400 MHz, CDCl3) δ (ppm): 4.52 (s, 2H, NH2); 3.02 (s, 2H, CH-C=O); 1.53 (s, 6H, CH3); 1.47 (s, 6H, CH3); 1.33 (dd, 2H, CH2).
13C-NMR (100 MHz, CDCl3) δ (ppm): 174.4, 137.6, 63.6, 55.2, 51.9, 17.1, 10.9.
ESI MS: m/z = 257.2 [M + Na]+ (100%).
Elemental Analysis: Calculated for C13H18O2N2(234.3): C, 66.07 %; H, 8.53 %; N, 11.85 %. Found: C, 66.32 %; H, 8.32 %; N, 11.89 %.

Supplementary materials

Supplementary File 1Supplementary File 2Supplementary File 3Supplementary File 4Supplementary File 5Supplementary File 6

References

  1. Kossakowski, J.; Kuśmierczyk, J. Acta Pol. Pharm. 1999, 56, 94.
  2. Mironov, V.A.; Sobolev, E.V.; Elizarova, A.N. Tetrahedron 1963, 19, 1939.

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MDPI and ACS Style

Struga, M.; Kossakowski, J. Synthesis of 4-Amino-1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione. Molbank 2007, 2007, M534. https://doi.org/10.3390/M534

AMA Style

Struga M, Kossakowski J. Synthesis of 4-Amino-1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione. Molbank. 2007; 2007(2):M534. https://doi.org/10.3390/M534

Chicago/Turabian Style

Struga, Marta, and Jerzy Kossakowski. 2007. "Synthesis of 4-Amino-1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione" Molbank 2007, no. 2: M534. https://doi.org/10.3390/M534

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