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Molbank 2012, 2012(3), M771; doi:10.3390/M771

3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride

1
Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India
2
Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India
3
Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India
*
Author to whom correspondence should be addressed.
Received: 29 June 2012 / Accepted: 15 August 2012 / Published: 17 August 2012
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Abstract

A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (3).
Keywords: spirocyclic; pyrazolone; reduction; N-arylation; amide coupling spirocyclic; pyrazolone; reduction; N-arylation; amide coupling
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MDPI and ACS Style

Srinivasan, R.; Narayana, B.; Samshuddin, S.; Sarojini, B.K. 3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride. Molbank 2012, 2012, M771.

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