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Molbank 2012, 2012(4), M781; doi:10.3390/M781
Short Note

2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV)

*  and
Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstra├če 14, A- 1090 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 27 June 2012 / Accepted: 27 September 2012 / Published: 1 October 2012
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Abstract

An aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.
Keywords: pyrrole; DNA-alkylation; anticancer pyrrole; DNA-alkylation; anticancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Spreitzer, H.; Puschmann, C. 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV). Molbank 2012, 2012, M781.

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