Next Article in Journal
Automated Counting of Airborne Asbestos Fibers by a High-Throughput Microscopy (HTM) Method
Next Article in Special Issue
Cell Docking, Movement and Cell-Cell Interactions of Heterogeneous Cell Suspensions in a Cell Manipulation Microdevice
Previous Article in Journal
Research on the Filtering Algorithm in Speed and Position Detection of Maglev Trains
Article Menu

Export Article

Open AccessArticle
Sensors 2011, 11(7), 7219-7230; doi:10.3390/s110707219

Development of Sensor Cells Using NF-κB Pathway Activation for Detection of Nanoparticle-Induced Inflammation

Cell-Materials Interaction Group, Biomaterials Unit, Nano-Bio Field, National Institute for Materials Science, 1-1, Namiki, Tsukuba, Ibaraki, 305-0044, Japan
Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555, Japan
TOTO Ltd. Research Institute, Nakashima 2-1-1, Kokurakita, Kitakyushu, 802-8601, Japan
Author to whom correspondence should be addressed.
Received: 10 June 2011 / Revised: 8 July 2011 / Accepted: 12 July 2011 / Published: 18 July 2011
(This article belongs to the Special Issue Live Cell-Based Sensors)
View Full-Text   |   Download PDF [579 KB, uploaded 21 June 2014]   |  


The increasing use of nanomaterials in consumer and industrial products has aroused concerns regarding their fate in biological systems. An effective detection method to evaluate the safety of bio-nanomaterials is therefore very important. Titanium dioxide (TiO2), which is manufactured worldwide in large quantities for use in a wide range of applications, including pigment and cosmetic manufacturing, was once thought to be an inert material, but recently, more and more studies have indicated that TiO2 nanoparticles (TiO2 NPs) can cause inflammation and be harmful to humans by causing lung and brain problems. In order to evaluate the safety of TiO2 NPs for the environment and for humans, sensor cells for inflammation detection were developed, and these were transfected with the Toll-like receptor 4 (TLR4) gene and Nuclear Factor Kappa B (NF-κB) reporter gene. NF-κB as a primary cause of inflammation has received a lot of attention, and it can be activated by a wide variety of external stimuli. Our data show that TiO2 NPs-induced inflammation can be detected by our sensor cells through NF-κB pathway activation. This may lead to our sensor cells being used for bio-nanomaterial safety evaluation. View Full-Text
Keywords: sensor cells; TiO2 nanoparticles agglomerates; inflammation; NF-κB; Toll-like receptor4 sensor cells; TiO2 nanoparticles agglomerates; inflammation; NF-κB; Toll-like receptor4

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, P.; Migita, S.; Kanehira, K.; Sonezaki, S.; Taniguchi, A. Development of Sensor Cells Using NF-κB Pathway Activation for Detection of Nanoparticle-Induced Inflammation. Sensors 2011, 11, 7219-7230.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top