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Sensors 2012, 12(11), 15907-15946; doi:10.3390/s121115907

Thiol Reactive Probes and Chemosensors

1
Department of Chemistry and the Center for Diagnostics and Therapeutics, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302, USA
2
Department of Chemistry, Portland State University, Portland, OR 97207, USA
*
Author to whom correspondence should be addressed.
Received: 24 September 2012 / Revised: 12 November 2012 / Accepted: 13 November 2012 / Published: 19 November 2012

Abstract

Thiols are important molecules in the environment and in biological processes. Cysteine (Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) play critical roles in a variety of physiological and pathological processes. The selective detection of thiols using reaction-based probes and sensors is very important in basic research and in disease diagnosis. This review focuses on the design of fluorescent and colorimetric probes and sensors for thiol detection. Thiol detection methods include probes and labeling agents based on nucleophilic addition and substitution, Michael addition, disulfide bond or Se-N bond cleavage, metal-sulfur interactions and more. Probes for H2S are based on nucleophilic cyclization, reduction and metal sulfide formation. Thiol probe and chemosensor design strategies and mechanism of action are discussed in this review.
Keywords: thiols; cysteine; homocysteine; glutathione; hydrogen sulfide; sensors; probes; detection thiols; cysteine; homocysteine; glutathione; hydrogen sulfide; sensors; probes; detection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Peng, H.; Chen, W.; Cheng, Y.; Hakuna, L.; Strongin, R.; Wang, B. Thiol Reactive Probes and Chemosensors. Sensors 2012, 12, 15907-15946.

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