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Sensors 2013, 13(3), 3975-3985; doi:10.3390/s130303975

Piper nigrum, Piper betle and Gnetum gnemon- Natural Food Sourcewith Anti-Quorum Sensing Properties

Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
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Received: 30 January 2013 / Revised: 5 March 2013 / Accepted: 10 March 2013 / Published: 20 March 2013
(This article belongs to the Section Biosensors)
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Abstract

Various parts of Piper nigrum, Piper betle and Gnetum gnemon are used as food sources by Malaysians. The purpose of this study is to examine the anti-quorum sensing (anti-QS) properties of P. nigrum, P. betle and G. gnemon extracts. The hexane, chloroform and methanol extracts of these plants were assessed in bioassays involving Pseudomonas aeruginosa PA01, Escherichia coli [pSB401], E. coli [pSB1075] and Chromobacterium violaceum CV026. It was found that the extracts of these three plants have anti-QS ability. Interestingly, the hexane, chloroform and methanol extracts from P. betle showed the most potent anti-QS activity as judged by the bioassays. Since there is a variety of plants that serve as food sources in Malaysia that have yet to be tested for anti-QS activity, future work should focus on identification of these plants and isolation of the anti-QS compounds. View Full-Text
Keywords: natural products; Pseudomonas aeruginosa; pathogenicity; pyocyanin; quorum sensing; quorum quenching; swarming; violacein; virulence natural products; Pseudomonas aeruginosa; pathogenicity; pyocyanin; quorum sensing; quorum quenching; swarming; violacein; virulence
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Tan, L.Y.; Yin, W.-F.; Chan, K.-G. Piper nigrum, Piper betle and Gnetum gnemon- Natural Food Sourcewith Anti-Quorum Sensing Properties. Sensors 2013, 13, 3975-3985.

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