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Sensors 2013, 13(5), 5777-5795; doi:10.3390/s130505777

Microbial Biosensors: Engineered Microorganisms as the Sensing Machinery

1 Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA 2 Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan
* Author to whom correspondence should be addressed.
Received: 11 March 2013 / Revised: 18 April 2013 / Accepted: 3 May 2013 / Published: 6 May 2013
(This article belongs to the Special Issue Live Cell-Based Sensors)
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Whole-cell biosensors are a good alternative to enzyme-based biosensors since they offer the benefits of low cost and improved stability. In recent years, live cells have been employed as biosensors for a wide range of targets. In this review, we will focus on the use of microorganisms that are genetically modified with the desirable outputs in order to improve the biosensor performance. Different methodologies based on genetic/protein engineering and synthetic biology to construct microorganisms with the required signal outputs, sensitivity, and selectivity will be discussed.
Keywords: synthetic biology; scaffolds; genetic circuits synthetic biology; scaffolds; genetic circuits
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Park, M.; Tsai, S.-L.; Chen, W. Microbial Biosensors: Engineered Microorganisms as the Sensing Machinery. Sensors 2013, 13, 5777-5795.

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