Sensors 2013, 13(5), 6423-6447; doi:10.3390/s130506423
Biosensors in Clinical Practice: Focus on Oncohematology
1
Department of Hematology-Oncology and BMT Unit, IRCCS CÃ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
2
Faculty of Medicine, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 6 March 2013 / Revised: 15 April 2013 / Accepted: 18 April 2013 / Published: 14 May 2013
(This article belongs to the Special Issue Live Cell-Based Sensors)
Abstract
Biosensors are devices that are capable of detecting specific biological analytes and converting their presence or concentration into some electrical, thermal, optical or other signal that can be easily analysed. The first biosensor was designed by Clark and Lyons in 1962 as a means of measuring glucose. Since then, much progress has been made and the applications of biosensors are today potentially boundless. This review is limited to their clinical applications, particularly in the field of oncohematology. Biosensors have recently been developed in order to improve the diagnosis and treatment of patients affected by hematological malignancies, such as the biosensor for assessing the in vitro pre-treatment efficacy of cytarabine in acute myeloid leukemia, and the fluorescence resonance energy transfer-based biosensor for assessing the efficacy of imatinib in chronic myeloid leukemia. The review also considers the challenges and future perspectives of biosensors in clinical practice.Keywords:
biosensors; leukemia; oncohematology; clinical applications
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style
Fracchiolla, N.S.; Artuso, S.; Cortelezzi, A. Biosensors in Clinical Practice: Focus on Oncohematology. Sensors 2013, 13, 6423-6447.