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Sensors 2006, 6(8), 860-873; doi:10.3390/s6080860

Nucleoside Sensing

1
Marburg University, Department of Chemistry, Hans-Meerwein-Strasse, 35032 Marburg, Germany
2
Duisburg-Essen University, Institute of Organic Chemistry, Universitätsstr. 5, 45117 Essen, Germany
*
Authors to whom correspondence should be addressed.
Received: 5 April 2006 / Accepted: 7 June 2006 / Published: 24 August 2006
(This article belongs to the Special Issue Supramolecular Sensors)
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Abstract

A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR spectrum. Nucleoside drugs can therefore be detected with high selectivity in thepresence of their phosphorylated pendants or nucleic acids.
Keywords: Nucleoside; Nucleotide; Molecular Clip; π-Stacking; NMR Sensing. Nucleoside; Nucleotide; Molecular Clip; π-Stacking; NMR Sensing.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fokkens, M.; Klärner, F.-G.; Schrader, T. Nucleoside Sensing. Sensors 2006, 6, 860-873.

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