Modelling Amperometric Biosensors Based on Chemically Modified Electrodes
AbstractThe response of an amperometric biosensor based on a chemically modified electrode was modelled numerically. A mathematical model of the biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments: an enzyme layer and an outer diffusion layer. In order to define the main governing parameters the corresponding dimensionless mathematical model was derived. The digital simulation was carried out using the finite difference technique. The adequacy of the model was evaluated using analytical solutions known for very specific cases of the model parameters. By changing model parameters the output results were numerically analyzed at transition and steady state conditions. The influence of the substrate and mediator concentrations as well as of the thicknesses of the enzyme and diffusion layers on the biosensor response was investigated. Calculations showed complex kinetics of the biosensor response, especially when the biosensor acts under a mixed limitation of the diffusion and the enzyme interaction with the substrate. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Baronas, R.; Kulys, J. Modelling Amperometric Biosensors Based on Chemically Modified Electrodes. Sensors 2008, 8, 4800-4820.
Baronas R, Kulys J. Modelling Amperometric Biosensors Based on Chemically Modified Electrodes. Sensors. 2008; 8(8):4800-4820.Chicago/Turabian Style
Baronas, Romas; Kulys, Juozas. 2008. "Modelling Amperometric Biosensors Based on Chemically Modified Electrodes." Sensors 8, no. 8: 4800-4820.