Table of Contents
Pharmaceuticals, Volume 10, Issue 4 (December 2017)
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Cover Story (view full-size image) In recent years Glu-ureido based radiotracers targeting the prostate-specific membrane antigen [...] Read more. In recent years Glu-ureido based radiotracers targeting the prostate-specific membrane antigen (PSMA) have demonstrated a high potential in the clinical management of prostate cancer patients. So far, the availability of radiolabelling precursors enabling batch productions yielding high activity amounts of the radiopharmaceutical for meeting the clinical demand in university hospitals remained a challenge. Our recently developed ligand [18F]PSMA-1007 is a possible candidate for bridging this gap. Within the present paper we report on a novel radiolabeling precursor and procedures for the GMP-compliant large scale production of this radioligand, representing an important milestone in a development which may eventually lead to an approved drug. View this paper