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Mar. Drugs 2013, 11(11), 4407-4418; doi:10.3390/md11114407

New Constituents from the Korean Sponge Plakortis simplex

1 Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Korea 2 College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Jeonbuk 570-749, Korea
* Author to whom correspondence should be addressed.
Received: 10 July 2013 / Revised: 30 September 2013 / Accepted: 14 October 2013 / Published: 5 November 2013
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Six new cyclic peroxides (16) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemical reactions. Compounds 16 exhibited cytotoxic/antifungal activities against RAW264.7 cells and Candida albicans.
Keywords: Plakortis simplex; cyclic peroxide; cyclic peroxyketal; pyridinium; NMR Plakortis simplex; cyclic peroxide; cyclic peroxyketal; pyridinium; NMR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Oh, J.S.; Hwang, B.S.; Kang, O.-H.; Kwon, D.-Y.; Rho, J.-R. New Constituents from the Korean Sponge Plakortis simplex. Mar. Drugs 2013, 11, 4407-4418.

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