Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites
AbstractDerivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A. View Full-Text
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Zur, L.G.; Bishara, A.; Aknin, M.; Neumann, D.; Ben-Califa, N.; Kashman, Y. Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites. Mar. Drugs 2013, 11, 4487-4509.
Zur LG, Bishara A, Aknin M, Neumann D, Ben-Califa N, Kashman Y. Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites. Marine Drugs. 2013; 11(11):4487-4509.Chicago/Turabian Style
Zur, Lee G.; Bishara, Ashgan; Aknin, Maurice; Neumann, Drorit; Ben-Califa, Nathalie; Kashman, Yoel. 2013. "Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites." Mar. Drugs 11, no. 11: 4487-4509.