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Mar. Drugs 2013, 11(2), 551-558; doi:10.3390/md11020551
Article

Isolation and Structural Elucidation of Chondrosterins F–H from the Marine Fungus Chondrostereum sp.

1
,
1
,
1
,
2
,
2
 and
3,4,*
1 School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China 2 State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China 3 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China 4 Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
* Author to whom correspondence should be addressed.
Received: 21 January 2013 / Revised: 13 February 2013 / Accepted: 18 February 2013 / Published: 22 February 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract

The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F–H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone (3), and (2E)-decene-4,6,8-triyn-1-ol (6), were isolated. Their structures were elucidated primarily based on NMR and MS data. Incarnal (2) exhibited potent cytotoxic activity against various cancer cell lines.
Keywords: Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, H.-J.; Chen, T.; Xie, Y.-L.; Chen, W.-D.; Zhu, X.-F.; Lan, W.-J. Isolation and Structural Elucidation of Chondrosterins F–H from the Marine Fungus Chondrostereum sp.. Mar. Drugs 2013, 11, 551-558.

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