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Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.
AbstractSeven new polyoxygenated steroids (1–7) were isolated together with seven known analogues (8–14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity.
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Wang, Z.; Tang, H.; Wang, P.; Gong, W.; Xue, M.; Zhang, H.; Liu, T.; Liu, B.; Yi, Y.; Zhang, W. Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.. Mar. Drugs 2013, 11, 775-787.View more citation formats
Wang Z, Tang H, Wang P, Gong W, Xue M, Zhang H, Liu T, Liu B, Yi Y, Zhang W. Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.. Marine Drugs. 2013; 11(3):775-787.Chicago/Turabian Style
Wang, Zenglei; Tang, Hua; Wang, Pan; Gong, Wei; Xue, Mei; Zhang, Hongwei; Liu, Taofang; Liu, Baoshu; Yi, Yanghua; Zhang, Wen. 2013. "Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.." Mar. Drugs 11, no. 3: 775-787.
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