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Mar. Drugs 2013, 11(4), 1162-1172; doi:10.3390/md11041162

Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.

1,*  and 1,*
1 School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China 2 College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China 3 Analytical and Testing Center, Wenzhou University, Wenzhou 325035, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 February 2013 / Revised: 18 March 2013 / Accepted: 23 March 2013 / Published: 3 April 2013
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Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 414. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 13 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
Keywords: soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhao, M.; Yin, J.; Jiang, W.; Ma, M.; Lei, X.; Xiang, Z.; Dong, J.; Huang, K.; Yan, P. Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.. Mar. Drugs 2013, 11, 1162-1172.

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