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Mar. Drugs 2013, 11(4), 1399-1408; doi:10.3390/md11041399

Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

These authors contributed equally to this work.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Received: 28 January 2013 / Revised: 25 March 2013 / Accepted: 7 April 2013 / Published: 23 April 2013
(This article belongs to the Special Issue Deep-Sea Natural Products)
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Abstract

A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 24, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. View Full-Text
Keywords: chlorinated eremophilane sesquiterpene; Antarctic deep-sea derived fungus; Penicillium sp. chlorinated eremophilane sesquiterpene; Antarctic deep-sea derived fungus; Penicillium sp.
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MDPI and ACS Style

Wu, G.; Lin, A.; Gu, Q.; Zhu, T.; Li, D. Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1. Mar. Drugs 2013, 11, 1399-1408.

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